局部用钙通道阻滞剂对类固醇性青光眼眼压的影响。
Effect of Topical Calcium Channel Blockers on Intraocular Pressure in Steroid-induced Glaucoma.
作者信息
Ganekal Sunil, Dorairaj Syril, Jhanji Vishal, Kudlu Krishnaprasad
机构信息
Assistant Professor, Department of Ophthalmology, JJM Medical College Davangere, Karnataka, India.
Associate Professor, Department of Ophthalmology, Mayo Clinic, Jacksonville Florida, USA.
出版信息
J Curr Glaucoma Pract. 2014 Jan-Apr;8(1):15-9. doi: 10.5005/jp-journals-10008-1155. Epub 2014 Jan 16.
PURPOSE
To evaluate the effect of 0.125% verapamil and 0.5% diltiazem eye drops on intraocular pressure (IOP) in steroid-induced glaucoma in rabbit eyes.
METHODS
A total of 18 rabbits with steroid-induced glaucoma were divided into three groups (A, B and C; n = 6 each). Right eyes in groups A, B and C received 0.5% diltiazem, 0.125% verapamil and 0.5% timolol eye drops twice daily for 12 days, respectively; whereas, left eyes received distilled water. IOP was measured with Tono-pen XL at baseline, day 4, day 8, and day 12 of treatment.
RESULTS
Both 0.5% diltiazem and 0.125% verapamil eye drops significantly reduced IOP compared to control eyes (p < 0.05). Reduction of IOP by 0.5% diltiazem, 0.125% verapamil eye drops were comparable to 0.5% timolol. No surface toxicity or systemic side effects were noted during the study period.
CONCLUSION
Calcium channel blockers, verapamil, and diltia-zem significantly reduced IOP in rabbiteyes. This group of drugs may have a potential role in treatment of glaucoma How to cite this article: Ganekal S, Dorairaj S, Jhanji V, Kudlu K. Effect of Topical Calcium Channel Blockers on Intraocular Pressure in Steroid-induced Glaucoma. J Current Glau Prac 2014;8(1):15-19.
目的
评估0.125%维拉帕米和0.5%地尔硫卓滴眼液对兔眼激素性青光眼眼压（IOP）的影响。
方法
将18只激素性青光眼兔分为三组（A、B和C组；每组n = 6）。A、B和C组的右眼分别每天两次给予0.5%地尔硫卓、0.125%维拉帕米和0.5%噻吗洛尔滴眼液，共12天；而左眼给予蒸馏水。在治疗的基线、第4天、第8天和第12天用Tono-pen XL测量眼压。
结果
与对照眼相比，0.5%地尔硫卓和0.125%维拉帕米滴眼液均显著降低了眼压（p < 0.05）。0.5%地尔硫卓、0.125%维拉帕米滴眼液降低眼压的效果与0.5%噻吗洛尔相当。在研究期间未观察到表面毒性或全身副作用。
结论
钙通道阻滞剂维拉帕米和地尔硫卓可显著降低兔眼眼压。这组药物可能在青光眼治疗中具有潜在作用。如何引用本文：Ganekal S, Dorairaj S, Jhanji V, Kudlu K. 局部钙通道阻滞剂对激素性青光眼眼压的影响。《J Current Glau Prac》2014；8(1):15 - 19。
Zotero 插件