Computational Cell Biology Group, Institute for Predictive and Personalized Medicine of Cancer, 08916 Badalona, Barcelona, Spain.
J Cell Biol. 2012 Jan 23;196(2):189-201. doi: 10.1083/jcb.201103008.
The Ras superfamily is a fascinating example of functional diversification in the context of a preserved structural framework and a prototypic GTP binding site. Thanks to the availability of complete genome sequences of species representing important evolutionary branch points, we have analyzed the composition and organization of this superfamily at a greater level than was previously possible. Phylogenetic analysis of gene families at the organism and sequence level revealed complex relationships between the evolution of this protein superfamily sequence and the acquisition of distinct cellular functions. Together with advances in computational methods and structural studies, the sequence information has helped to identify features important for the recognition of molecular partners and the functional specialization of different members of the Ras superfamily.
Ras 超家族是在保留结构框架和典型 GTP 结合位点的情况下功能多样化的一个引人入胜的例子。由于具有代表重要进化分支点的物种的完整基因组序列，我们在比以前更大的程度上分析了这个超家族的组成和组织。在生物体和序列水平上对基因家族的系统发育分析揭示了该蛋白质超家族序列的进化与独特细胞功能的获得之间的复杂关系。与计算方法和结构研究的进步一起，序列信息有助于确定识别分子伴侣和 Ras 超家族不同成员功能专业化的重要特征。
