Russo Vincenzo, Stella Andrea, Barone Antonio, Scott Ingrid U, Noci Nicola Delle
Institute of Ophthalmology, University of Foggia, viale Luigi Pinto, 71100 Foggia, Italy.
Int Ophthalmol. 2012 Feb;32(1):71-5. doi: 10.1007/s10792-011-9513-1. Epub 2012 Jan 22.
The purpose of this study is to report a case of retinal capillary hemangioma treated with ruthenium-106 brachytherapy combined with intravitreal bevacizumab. A 58-year-old woman presented with blurred vision in her left eye for 15 days. Best-corrected visual acuity (BCVA) was counting fingers at 3 m in her left eye. Examination showed a peripheral endophytic retinal capillary hemangioma, with associated macular edema and diffuse hard exudates in a macular star pattern. B-scan ultrasonography revealed a solid, highly reflective retinal tumor measuring 7.1 × 7.5 mm in basal dimension and 3.5 mm in thickness. The hemangioma and macular edema were treated with ruthenium-106 brachytherapy (500 Gy) followed 1 month later with an intravitreal injection of 1.25 mg (0.05 ml) bevacizumab. After 10 months of follow-up, examination demonstrated involution of the hemangioma, resolution of the macular edema, less hard exudates, and improvement of BCVA to 20/25. Ruthenium-106 brachytherapy combined with intravitreal bevacizumab was associated with significant involution of the choroidal hemangioma with resolution of the macular edema and improvement in visual acuity.
本研究的目的是报告一例采用钌 - 106近距离放射治疗联合玻璃体内注射贝伐单抗治疗视网膜毛细血管瘤的病例。一名58岁女性因左眼视力模糊15天就诊。其左眼最佳矫正视力（BCVA）为3米处数指。检查发现周边内生性视网膜毛细血管瘤，伴有黄斑水肿及黄斑星芒状分布的弥漫性硬性渗出。B超检查显示一个实性、高反射性视网膜肿瘤，基底尺寸为7.1×7.5毫米，厚度为3.5毫米。对该毛细血管瘤及黄斑水肿采用钌 - 106近距离放射治疗（500 Gy），1个月后玻璃体内注射1.25毫克（0.05毫升）贝伐单抗。经过10个月的随访，检查显示毛细血管瘤消退，黄斑水肿消退，硬性渗出减少，BCVA提高至20/25。钌 - 106近距离放射治疗联合玻璃体内注射贝伐单抗与脉络膜血管瘤显著消退、黄斑水肿消退及视力改善相关。
