UMR 7245 CNRS-MNHN Molécules de Communication et Adaptation des Micro-organismes, Muséum National d'Histoire Naturelle, Paris, France.
Planta Med. 2012 Mar;78(5):459-64. doi: 10.1055/s-0031-1298156. Epub 2012 Jan 23.
Two new polyprenylated acylphloroglucinols, spiranthenones A (1) and B (2), a sesquiterpenoid, 6 α-acetoxy,1 β-hydroxyeudesm-4(15)-ene (3), along with sesamin and β-sitosterol, were isolated from the EtOAc extract of the leaves of Spiranthera odoratissima, and shown to display antiprotozoal activity. Their structures and relative stereochemistry were elucidated by NMR and mass spectrometry. These compounds exhibited moderate antiprotozoal activity, but without significant cytotoxicity against fibroblasts cell line NIH-3T3. Compound 3 was the most selective towards parasites.
从 Spiranthera odoratissima 的叶的 EtOAc 提取物中分离得到了两种新的多聚异戊二烯酰基间苯三酚，螺旋酮 A（1）和 B（2），一种倍半萜，6α-乙酰氧基，1β-羟基桉叶-4(15)-烯（3），以及芝麻素和β-谷甾醇，并显示出抗原生动物活性。通过 NMR 和质谱法阐明了它们的结构和相对立体化学。这些化合物表现出中等的抗原生动物活性，但对成纤维细胞系 NIH-3T3 没有明显的细胞毒性。化合物 3 对寄生虫的选择性最高。
