因吸食含有 3,4-亚甲基二氧吡咯戊酮（MDPV）的“浴盐”等娱乐性药物而死亡。
Death following recreational use of designer drug "bath salts" containing 3,4-Methylenedioxypyrovalerone (MDPV).
机构信息
Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28232, USA.
出版信息
J Med Toxicol. 2012 Mar;8(1):69-75. doi: 10.1007/s13181-011-0196-9.
Abstract
INTRODUCTION
3,4-Methylenedioxypyrovalerone (MDPV) is a designer stimulant drug that has gained popularity in the USA. Although adverse effects of MDPV have been described, to our knowledge, this is the first reported death.
CASE REPORT
We report the case of a 40-year-old male who injected and snorted "bath salts" containing MDPV and subsequently became agitated, aggressive, and experienced a cardiac arrest. He was resuscitated after his initial arrest; however, he developed hyperthermia, rhabdomyolysis, coagulopathy, acidosis, anoxic brain injury, and subsequently died.
DISCUSSION
This is the first case in the medical literature to report death due to isolated confirmed MDPV intoxication. The manner of death is also consistent with excited delirium syndrome.
摘要
简介
3,4-亚甲二氧基吡咯戊酮（MDPV）是一种流行于美国的苯丙胺类兴奋剂。尽管已有关于 MDPV 不良反应的报道，但据我们所知，这是首例死亡报告。
病例报告
我们报告了一例 40 岁男性的病例，该男性注射并吸食了含有 MDPV 的“浴盐”，随后出现烦躁、攻击性，并发生心脏骤停。他在最初的心脏骤停后被复苏；然而，他随后出现高热、横纹肌溶解、凝血功能障碍、酸中毒、缺氧性脑损伤，并最终死亡。
讨论
这是医学文献中首例因确诊的 MDPV 中毒而导致的死亡案例。死亡方式也与兴奋型谵妄综合征一致。
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Clin Toxicol (Phila). 2011 Jul;49(6):499-505. doi: 10.3109/15563650.2011.590812.
2
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Gen Hosp Psychiatry. 2011 Sep-Oct;33(5):525-6. doi: 10.1016/j.genhosppsych.2011.05.014. Epub 2011 Jul 16.
3
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Gen Hosp Psychiatry. 2011 Nov-Dec;33(6):640.e5-6. doi: 10.1016/j.genhosppsych.2011.04.010. Epub 2011 May 26.
4
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5
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