Chu Quyen, Jaganmohan Sathya, Kelly Brandi, Hobley James
Division of Surgical Oncology, Louisiana State University Health Science Center, Feist-Weiller Cancer Center, Shreveport, USA.
J La State Med Soc. 2011 Sep-Oct;163(5):251-3.
Verrucous carcinoma of the esophagus is an extremely rare entity. It is associated with severe epithelial hyperplasia and parakeratosis of the epithelial layers. Superficial biopsies are usually falsely negative for malignant cells, as the biopsied mucosa usually demonstrates the hyperplastic epithelium. The tumor spread is through submucosal and paraesophageal infiltration. Endoscopically, verrucous carcinoma appears as a wartlike, exophytic lesion, hence the name verrucous. The diagnosis can be difficult to make, even after repeated endoscopic biopsies. We report a rare case of verrucous carcinoma of the esophagus in a 45-year-old man whose final pathologic diagnosis was confirmed only after an Ivor-Lewis esophagectomy was performed.
食管疣状癌是一种极其罕见的疾病。它与上皮层的严重上皮增生和不全角化有关。浅表活检通常对恶性细胞呈假阴性，因为活检的黏膜通常显示增生的上皮。肿瘤通过黏膜下和食管旁浸润扩散。在内镜下，疣状癌表现为疣状、外生性病变，因此得名疣状。即使经过多次内镜活检，诊断也可能很困难。我们报告了一例45岁男性食管疣状癌的罕见病例，其最终病理诊断仅在进行了艾弗-刘易斯食管切除术后才得以证实。
