1 Department of Family Medicine, Mayo Clinic, Rochester, Minnesota, USA 2 Departments of Psychiatry, Mayo Clinic, Rochester, Minnesota, USA.
Patient. 2008 Jul 1;1(3):165-72. doi: 10.2165/1312067-200801030-00003.
Medical visits are initiated by patients in search of symptom relief. The extent to which obesity independently increases the risk of common symptoms is unknown.
To assess how obesity affects symptom burden among family medicine patients, after adjustment for severity of illness, via retrospective analysis of electronic medical records pertaining to 1738 adult family medicine patients treated in a large family medicine department in Rochester, Minnesota, USA.
A symptom index was used to measure symptom burden. Body mass index (BMI; kg/m) was measured during clinic visits. Multiple logistic regression analysis was used to test for an independent relationship between BMI category and the presence of three or more common symptoms.
Adjusting for co-morbidity and other confounders using multiple logistic regression analysis revealed that having a BMI ≥35 kg/m was independently related to symptom burden (adjusted odds ratio [OR] = 1.80; 95% CI 1.24, 2.63). Patients with low and moderate co-morbidities (as measured by the Charlson Co-morbidity Index) also had higher odds of reporting more symptoms (OR = 1.60; 95% CI 1.17, 2.17 and OR = 1.87; 95% CI 1.36, 2.56, respectively). Symptom burden increased with age. Odds of having three or more symptoms were lower for married patients (OR 0.63; 95% CI 0.47, 0.83).
In our sample of family medicine patients, increased symptom burden may be associated with a BMI ≥35 kg/m. Lower levels of obesity do not appear to be related to symptom burden.
患者寻求症状缓解而发起医疗就诊。肥胖症独立增加常见症状风险的程度尚不清楚。
通过对美国明尼苏达州罗切斯特市一个大型家庭医学系的 1738 名成年家庭医学患者的电子病历进行回顾性分析，评估肥胖症如何在调整疾病严重程度后影响家庭医学患者的症状负担。
使用症状指数来衡量症状负担。在就诊期间测量体重指数（BMI；kg/m）。使用多变量逻辑回归分析来测试 BMI 类别与三种或更多种常见症状存在之间的独立关系。
使用多变量逻辑回归分析调整合并症和其他混杂因素后，发现 BMI≥35 kg/m 与症状负担独立相关（调整后的优势比 [OR] = 1.80；95%置信区间 1.24，2.63）。患有低中度合并症（通过 Charlson 合并症指数测量）的患者也更有可能报告更多的症状（OR=1.60；95%置信区间 1.17，2.17 和 OR=1.87；95%置信区间 1.36，2.56）。症状负担随年龄增长而增加。已婚患者出现三种或更多种症状的几率较低（OR 0.63；95%置信区间 0.47，0.83）。
在我们的家庭医学患者样本中，症状负担增加可能与 BMI≥35 kg/m 有关。较低水平的肥胖症似乎与症状负担无关。
