手性布朗斯台德酸催化的醛与烯丙基硼酸酯的对映选择性炔丙基化反应。
Chiral Brønsted acid catalyzed enantioselective propargylation of aldehydes with allenylboronate.
机构信息
Chemical and Analytical Development, Novartis Pharmaceutical Corporation, East Hanover, New Jersey 07936, USA.
出版信息
Org Lett. 2012 Feb 17;14(4):1142-5. doi: 10.1021/ol300075n. Epub 2012 Jan 24.
PMID:22273041
Abstract
A highly enantioselective chiral Brønsted acid catalyzed propargylation of aldehydes with allenylboronate is described. The reaction is shown to be practical and quite general with a broad substrate scope covering aryl, polyaryl, heteroaryl, α,β-unsaturated, and aliphatic aldehydes.
摘要
描述了一种高对映选择性手性 Brønsted 酸催化的醛与丙炔基硼酸酯的加成反应。该反应具有广泛的底物适用性，涵盖芳基、多芳基、杂芳基、α,β-不饱和和脂肪醛，是实用且非常通用的。
Zotero 插件