通过布朗斯特酸催化实现（）-1,3-丁二烯基-2-甲醇的立体选择性和对映选择性合成。
Stereo- and Enantioselective Syntheses of ()-1,3-Butadienyl-2-carbinols via Brønsted Acid Catalysis.
作者信息
Chen Ming
机构信息
Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, United States.
出版信息
Org Lett. 2025 Jan 24;27(3):887-891. doi: 10.1021/acs.orglett.4c04663. Epub 2025 Jan 9.
Abstract
A Brønsted acid-catalyzed enantioselective synthesis of ()-1,3-butadienyl-2-carbinols is developed. By employing a chiral phosphoric acid as the catalyst, a variety of 1,3-butadienyl-2-carbinols were obtained in good yields with excellent -selectivities and enantiopurities from α-alkyl-substituted homoallenyl boronates.
摘要
开发了一种布朗斯特酸催化的对映选择性合成（）-1,3-丁二烯基-2-甲醇的方法。通过使用手性磷酸作为催化剂，从α-烷基取代的高烯丙基硼酸酯中以良好的产率、优异的非对映选择性和对映体纯度获得了多种1,3-丁二烯基-2-甲醇。
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