Ma Dawei, Jiang Yongwen
State Key Laboratory of Bioorganic and Natural Products Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 LingLing Road Shanghai 200032, China.
Chimia (Aarau). 2011;65(12):914-8. doi: 10.2533/chimia.2011.914.
Amino acids can be used as ligands to promote Ullmann-type coupling reactions. This review briefly discusses how L-proline, 4-hydroxy-L-proline and N,N-dimethylglycine can serve as the ideal ligands for copper-catalyzed coupling of aryl halides with different nucleophiles. Seven examples of applications of copper/amino acid catalyzed reactions in large-scale preparations are described.
氨基酸可作为配体促进乌尔曼型偶联反应。本综述简要讨论了L-脯氨酸、4-羟基-L-脯氨酸和N,N-二甲基甘氨酸如何作为铜催化芳基卤化物与不同亲核试剂偶联反应的理想配体。描述了铜/氨基酸催化反应在大规模制备中的七个应用实例。
