University of Southern Denmark, Department of Biochemistry and Molecular Biology, Campusvej 55, DK-5230, Odense M, Denmark.
Semin Cell Dev Biol. 2012 Aug;23(6):631-9. doi: 10.1016/j.semcdb.2012.01.003. Epub 2012 Jan 18.
The peroxisome proliferator activated receptors (PPARs) are nuclear receptors that play key roles in the regulation of lipid metabolism, inflammation, cellular growth, and differentiation. The receptors bind and are activated by a broad range of fatty acids and fatty acid derivatives and they thereby serve as major transcriptional sensors of fatty acids. Here we review the function, regulation, and mechanism of the different PPAR subtypes with special emphasis on their role in the regulation of lipid metabolism.
过氧化物酶体增殖物激活受体 (PPARs) 是核受体，在脂质代谢、炎症、细胞生长和分化的调节中发挥关键作用。这些受体结合并被广泛的脂肪酸和脂肪酸衍生物激活，因此它们是脂肪酸的主要转录传感器。本文综述了不同 PPAR 亚型的功能、调节和机制，特别强调了它们在脂质代谢调节中的作用。
