Cátedra de Inmunología, Facultad de Ciencias/Química, Universidad de la República, Montevideo, Uruguay.
Free Radic Biol Med. 2012 Nov 1;53(9):1654-63. doi: 10.1016/j.freeradbiomed.2012.08.572. Epub 2012 Aug 30.
Lipid nitration has been observed during oxidative/nitrative stress conditions generating a variety of biomolecules capable of modulating cellular responses. This concept has grown as a result of studies with nitro-derivatives of long-chain unsaturated fatty acids containing a nitroalkene group (nitro-fatty acids). This review focuses on the interactions of nitro-fatty acids with members of the peroxisome proliferator-activated receptors (PPARs) family. These nuclear receptors belong to a superfamily of ligand-activated transcription factors, which serve as sensors of lipophilic molecules and regulate the expression of a set of genes involved in glucose and lipid metabolism. Here we discuss how nitro-fatty acids bind and activate PPARs, including the current knowledge of the molecular interactions and cell signaling events involved as well as their therapeutic potential associated with chronic inflammation and metabolic disorders.
脂质硝化作用发生在氧化/硝化应激条件下，产生多种能够调节细胞反应的生物分子。这一概念随着含有硝基烯基团的长链不饱和脂肪酸的硝基衍生物（硝基脂肪酸）的研究而发展起来。本综述重点介绍了硝基脂肪酸与过氧化物酶体增殖物激活受体（PPARs）家族成员的相互作用。这些核受体属于配体激活转录因子的超家族，作为亲脂性分子的传感器，调节参与葡萄糖和脂质代谢的一组基因的表达。在这里，我们讨论了硝基脂肪酸如何结合和激活 PPARs，包括目前对涉及的分子相互作用和细胞信号事件的了解，以及它们与慢性炎症和代谢紊乱相关的治疗潜力。
