Maltbie A A, Cavenar J O, Sullivan J L, Hammett E B, Zung W W
J Clin Psychiatry. 1979 Jul;40(7):323-6.
We have previously reported 10 patient histories involving various intractable pain syndromes where the administration of Haloperidol either eliminated the need for narcotic analgesics or resulted in a significant reduction in narcotic dosage. We are presently undertaking a controlled double-blind evaluation of Haloperidol as an adjunctive treatment for intractable cancer pain. Based upon the reported clinical observations, these findings are discussed from the following aspects: 1. The isomeric similarity of Haloperidol to Meperidine. 2. Dose response between Haloperidol and analgesic effect. 3. The clinical literature regarding the use of Haloperidol for the effective withdrawal or maintenance of narcotic addicts. 4. The analgesic property as it relates to the opiate receptor.
我们之前曾报告过10例涉及各种顽固性疼痛综合征的患者病史，其中给予氟哌啶醇后，要么不再需要使用麻醉性镇痛药，要么导致麻醉剂用量显著减少。我们目前正在对氟哌啶醇作为顽固性癌症疼痛辅助治疗进行对照双盲评估。基于已报告的临床观察结果，从以下几个方面对这些发现进行讨论：1. 氟哌啶醇与哌替啶的异构体相似性。2. 氟哌啶醇与镇痛效果之间的剂量反应。3. 关于使用氟哌啶醇有效戒除或维持麻醉品成瘾者的临床文献。4. 与阿片受体相关的镇痛特性。
