Akin Takmaz Suna, Inan Nurten, Günal Solmaz, Kaymak Cetin, Sakalli Melike, Dikmen Bayazit
Ministry of Health Ankara Training and Research Hospital, Anesthesiology and Reanimation Department, Ankara, Turkey.
Agri. 2005 Jul;17(3):44-7.
Pain treatment of patients with opioid addiction and tolerance may be challenging due to their unexpectedly higher pain sensitivities and opioid requirements. It has been reported that the N-methyl-D-aspartate receptor is involved in mechanisms of tolerance to opioid analgesics. Recently enhancement of morphine induced analgesia by low dose ketamine addition to the treatment regimen has been reported. We report a cancer patient with meperidine tolerance and psychological dependency to the agent who was afterwards successfully treated with morphine-ketamine combination.
对于有阿片类药物成瘾和耐受性的患者，疼痛治疗可能具有挑战性，因为他们的疼痛敏感性和阿片类药物需求量出人意料地更高。据报道，N-甲基-D-天冬氨酸受体参与了对阿片类镇痛药的耐受机制。最近有报道称，在治疗方案中添加低剂量氯胺酮可增强吗啡诱导的镇痛作用。我们报告了一名对哌替啶耐受且对该药物有心理依赖的癌症患者，该患者随后成功接受了吗啡-氯胺酮联合治疗。
