钯催化的 2-炔基溴苯、2-炔基苯胺和亲电试剂的三组分反应：一种高效合成各种 11H-茚并[1,2-c]喹啉的方法。
Palladium-catalyzed three-component reaction of 2-alkynylbromobenzene, 2-alkynylaniline, and electrophile: an efficient pathway for the synthesis of diverse 11H-indeno[1,2-c]quinolines.
机构信息
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China.
出版信息
Org Biomol Chem. 2012 Mar 14;10(10):1969-75. doi: 10.1039/c2ob06764a. Epub 2012 Jan 25.
PMID:22274301
Abstract
Diverse 11H-indeno[1,2-c]quinolines are produced via a palladium-catalyzed three-component reaction of 2-alkynylbromobenzene, 2-alkynylaniline, and electrophile. This conversion tolerates a wide variety of functionality and substitution patterns on the 11H-indeno[1,2-c]quinoline ring.
摘要
钯催化的 2-炔基溴苯、2-炔基苯胺和亲电试剂的三组分反应可以生成多样的 11H-茚并[1,2-c]喹啉。该转化可以容忍 11H-茚并[1,2-c]喹啉环上各种官能团和取代模式。
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