通过钯催化邻卤代苯乙炔与胺的串联反应高效合成 5H-环戊[c]喹啉衍生物。
Efficient synthesis of 5H-cyclopenta[c]quinoline derivatives via palladium-catalyzed domino reactions of o-alkynylhalobenzene with amine.
机构信息
Department of Chemistry, Fudan University, Shanghai, People's Republic of China.
出版信息
Org Lett. 2011 Mar 4;13(5):1150-3. doi: 10.1021/ol103173v. Epub 2011 Feb 9.
PMID:21306155
Abstract
A novel and efficient route for the synthesis of 5H-cyclopenta[c]quinoline derivatives via a palladium-catalyzed domino reaction of o-alkynylhalobenzene with amine is described. The starting materials are easily available, and the reaction proceeds smoothly with high efficiency, which shows broad scope with good functional group tolerance.
摘要
通过钯催化邻炔基卤代苯与胺的串联反应，我们描述了一种合成 5H-环戊并[c]喹啉衍生物的新颖、高效途径。该反应的起始原料易得，反应条件温和，具有高效、广泛的官能团容忍度等优点。
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