John Ines Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom.
Plant Cell. 2012 Jan;24(1):152-62. doi: 10.1105/tpc.111.094771. Epub 2012 Jan 24.
Despite possessing multiple sets of related (homoeologous) chromosomes, hexaploid wheat (Triticum aestivum) restricts pairing to just true homologs at meiosis. Deletion of a single major locus, Pairing homoeologous1 (Ph1), allows pairing of homoeologs. How can the same chromosomes be processed as homologs instead of being treated as nonhomologs? Ph1 was recently defined to a cluster of defective cyclin-dependent kinase (Cdk)-like genes showing some similarity to mammalian Cdk2. We reasoned that the cluster might suppress Cdk2-type activity and therefore affect replication and histone H1 phosphorylation. Our study does indeed reveal such effects, suggesting that Cdk2-type phosphorylation has a major role in determining chromosome specificity during meiosis.
尽管六倍体小麦 (Triticum aestivum) 拥有多套相关的 (同源) 染色体,但它在减数分裂过程中仅将真正的同源染色体进行配对。缺失一个主要基因座 Pairing homoeologous1 (Ph1) 可以允许同源染色体配对。那么,同一对染色体如何被视为同源染色体而不是非同源染色体进行处理呢?Ph1 最近被定义为一组缺陷的细胞周期蛋白依赖性激酶(Cdk)样基因簇,与哺乳动物 Cdk2 有一定的相似性。我们推测该基因簇可能抑制 Cdk2 型活性,从而影响复制和组蛋白 H1 的磷酸化。我们的研究确实揭示了这样的影响,表明 Cdk2 型磷酸化在决定减数分裂过程中染色体特异性方面起着重要作用。