Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Fondation de Recherche Cancer et Sang, Hôpital Kirchberg, 9 Rue Edward Steichen, 2540, Luxembourg, Luxembourg.
Genes Nutr. 2012 Apr;7(2):111-25. doi: 10.1007/s12263-012-0281-y. Epub 2012 Jan 25.
Signal transducers and activators of transcription (STAT) proteins were described as a family of latent cytosolic transcription factors whose activation is dependent on phosphorylation via growth factor- and cytokine-membrane receptors including interferon and interleukin, or by non-receptor intracellular tyrosine kinases, including Src. A vast majority of natural substances are capable of modulating mitogenic signals, cell survival, apoptosis, cell cycle regulation, angiogenesis as well as processes involved in metastasis development. The inhibition of STAT3 phosphorylation by natural and dietary compounds leads to decreased protein expression of STAT3 targets essentially involved in regulation of the cell cycle and apoptotic cell death. This review details the cell signaling pathways involving STAT transcription factors as well as the corresponding compounds from nature able to interfere with this regulatory system in human cancer.
信号转导子和转录激活子（STAT）蛋白被描述为一组潜在的细胞质转录因子家族，其激活依赖于生长因子和细胞因子膜受体（包括干扰素和白细胞介素）或非受体细胞内酪氨酸激酶（包括 Src）的磷酸化。绝大多数天然物质能够调节有丝分裂信号、细胞存活、细胞凋亡、细胞周期调控、血管生成以及转移发展过程中涉及的过程。天然和膳食化合物抑制 STAT3 磷酸化会导致 STAT3 靶蛋白的表达减少，这些靶蛋白主要参与细胞周期和细胞凋亡的调控。本综述详细介绍了涉及 STAT 转录因子的细胞信号通路，以及能够干扰人类癌症中这种调节系统的天然相应化合物。
