State Key Laboratory of New Ceramic and Fine Processing, Department of Materials Science and Engineering, Tsinghua University, Beijing, China.
J Biomater Appl. 2013 Jul;28(1):12-9. doi: 10.1177/0885328211433618. Epub 2012 Jan 24.
In this study, the biocompatibility and bone regeneration performance of nano-hydroxyapatite/collagen/poly(L-lactide) (nHAC/PLA) and nano-hydroxyapatite/collagen/calcium sulfate hemihydrate (nHAC/CSH) as bone-filling materials were evaluated and compared in a critical box-shaped defect model in the mandible of the rabbits. In vivo results indicated that there was significant difference in early bone remodeling between two types of bone substitutes. nHAC/PLA has shown excellent biocompatibility, but no adequate handling properties. The addition of CSH to nHAC provided better manipulability compared to nHAC/PLA. Furthermore, nHAC/CSH possesses superior properties in restoring critical-sized bone defects of maxillofacial region at the early stage of remodeling over nHAC/PLA. Our results suggested that nHAC/CSH could be an alternative to the conventionally used bone tissue engineering materials.
在这项研究中，我们评估并比较了纳米羟基磷灰石/胶原蛋白/聚（L-乳酸）（nHAC/PLA）和纳米羟基磷灰石/胶原蛋白/半水硫酸钙（nHAC/CSH）这两种作为骨填充材料的生物相容性和骨再生性能，在兔下颌骨的临界盒形缺损模型中进行了研究。体内结果表明，两种骨替代物的早期骨重塑有显著差异。nHAC/PLA 表现出良好的生物相容性，但操作性不佳。与 nHAC/PLA 相比，向 nHAC 中添加 CSH 可提供更好的操作性。此外，nHAC/CSH 在修复早期重塑阶段的颌面区域临界尺寸骨缺损方面具有优于 nHAC/PLA 的性能。我们的结果表明，nHAC/CSH 可能是传统骨组织工程材料的替代品。
