Damaging loss of self-control by stressed β-cells.

作者信息

Holness Mark J, Sugden Mary C

机构信息

Centre for Diabetes, Blizard Institute, St Bartholomew’s and the Royal London School of Medicine and Dentistry, Queen Mary, University of London, London, UK.

出版信息

Diabetes. 2012 Feb;61(2):267-9. doi: 10.2337/db11-1647.

DOI:10.2337/db11-1647

PMID:22275082

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3266421/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75da/3266421/84a6e7b7a62a/267fig1.jpg

相似文献

Damaging loss of self-control by stressed β-cells.

Diabetes. 2012 Feb;61(2):267-9. doi: 10.2337/db11-1647.

Assessment of insulin resistance and its role in non-insulin-dependent diabetes mellitus.

J Lab Clin Med. 1984 Apr;103(4):497-505.

[2004 Apollinaire Bouchardat prize. Muscle gene expression regulation by insulin. Abnormalities in type 2 diabetes].

Journ Annu Diabetol Hotel Dieu. 2004:39-45.

Aspects of the regulation of glucose transport in insulin-sensitive tissues in normal conditions and in type-2 diabetes.

Biochem Soc Trans. 1990 Dec;18(6):1127-30. doi: 10.1042/bst0181127.

Correlation of in vivo and in vitro actions of insulin in obesity and noninsulin-dependent diabetes mellitus: role of the glucose transport system.肥胖症和非胰岛素依赖型糖尿病中胰岛素体内和体外作用的相关性：葡萄糖转运系统的作用

Diabetes Metab Rev. 1988 Sep;4(6):543-69. doi: 10.1002/dmr.5610040602.

[From obesity to diabetes or the natural history of abnormalities in the secretion and action of insulin].[从肥胖到糖尿病或胰岛素分泌与作用异常的自然史]

Rev Med Liege. 1992 Jul;47(7):325-37.

Impaired glycogen synthesis of skeletal muscle in patients with insulin-resistant diabetes mellitus.

J Diabetes Complications. 1994 Oct-Dec;8(4):213-20. doi: 10.1016/1056-8727(94)90046-9.

Diagnosis of insulin resistance and associated syndromes: the spectrum from the metabolic syndrome to type 2 diabetes mellitus.胰岛素抵抗及相关综合征的诊断：从代谢综合征到2型糖尿病的范围

Coron Artery Dis. 2005 Dec;16(8):465-72. doi: 10.1097/00019501-200512000-00002.

Fatty acids and insulin resistance.脂肪酸与胰岛素抵抗

Diabetes Care. 1996 Apr;19(4):394-5. doi: 10.2337/diacare.19.4.394.

Protein kinase C-β contributes to impaired endothelial insulin signaling in humans with diabetes mellitus.蛋白激酶 C-β 促使糖尿病患者的血管内皮胰岛素信号转导受损。

Circulation. 2013 Jan 1;127(1):86-95. doi: 10.1161/CIRCULATIONAHA.112.127514. Epub 2012 Nov 30.

引用本文的文献

The effect of insulin administration on c-peptide in critically ill patients with type 2 diabetes.胰岛素给药对2型糖尿病重症患者C肽的影响。

Ann Intensive Care. 2017 Dec;7(1):50. doi: 10.1186/s13613-017-0274-5. Epub 2017 May 12.

本文引用的文献

Insulin augmentation of glucose-stimulated insulin secretion is impaired in insulin-resistant humans.在胰岛素抵抗的人群中，葡萄糖刺激的胰岛素分泌的胰岛素增强作用受损。

Diabetes. 2012 Feb;61(2):301-9. doi: 10.2337/db11-1067.

Influence of hyperinsulinemia and insulin resistance on in vivo β-cell function: their role in human β-cell dysfunction.高胰岛素血症和胰岛素抵抗对体内β细胞功能的影响：它们在人类β细胞功能障碍中的作用。

Diabetes. 2011 Dec;60(12):3141-7. doi: 10.2337/db11-0827. Epub 2011 Oct 25.

Insulin enhances glucose-stimulated insulin secretion in healthy humans.胰岛素增强健康人体的葡萄糖刺激胰岛素分泌。

Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4770-5. doi: 10.1073/pnas.1000002107. Epub 2010 Feb 22.

High glucose induces suppression of insulin signalling and apoptosis via upregulation of endogenous IL-1beta and suppressor of cytokine signalling-1 in mouse pancreatic beta cells.高葡萄糖通过上调内源性白细胞介素-1β和细胞因子信号转导抑制因子-1诱导小鼠胰岛β细胞胰岛素信号转导抑制和细胞凋亡。

Cell Signal. 2010 May;22(5):791-800. doi: 10.1016/j.cellsig.2010.01.003. Epub 2010 Jan 11.

Identification of insulin signaling elements in human beta-cells: autocrine regulation of insulin gene expression.人类β细胞中胰岛素信号元件的鉴定：胰岛素基因表达的自分泌调节

Diabetes. 2006 Oct;55(10):2835-42. doi: 10.2337/db06-0532.

Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells.胰岛素受体底物-1缺陷型β细胞生长与凋亡的改变。

Am J Physiol Endocrinol Metab. 2005 Aug;289(2):E337-46. doi: 10.1152/ajpendo.00032.2004. Epub 2005 Apr 12.

Islet secretory defect in insulin receptor substrate 1 null mice is linked with reduced calcium signaling and expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2b and -3.胰岛素受体底物1基因敲除小鼠的胰岛分泌缺陷与钙信号传导降低以及肌浆网/内质网Ca2+ -ATP酶（SERCA）-2b和-3的表达减少有关。

Diabetes. 2004 Jun;53(6):1517-25. doi: 10.2337/diabetes.53.6.1517.

Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance.

J Biol Chem. 2002 Sep 27;277(39):36740-7. doi: 10.1074/jbc.M206314200. Epub 2002 Jul 5.

Effects of glucose, exogenous insulin, and carbachol on C-peptide and insulin secretion from isolated perifused rat islets.

J Biol Chem. 2002 Jul 19;277(29):26233-7. doi: 10.1074/jbc.M202291200. Epub 2002 May 13.

beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass.胰岛β细胞特异性缺失胰岛素样生长因子1受体导致高胰岛素血症和葡萄糖不耐受，但不改变β细胞质量。

Nat Genet. 2002 May;31(1):111-5. doi: 10.1038/ng872. Epub 2002 Apr 1.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验