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Correlation of in vivo and in vitro actions of insulin in obesity and noninsulin-dependent diabetes mellitus: role of the glucose transport system.

作者信息

Garvey W T, Kolterman O G

机构信息

Department of Medicine, University of California School of Medicine, La Jolla 92093.

出版信息

Diabetes Metab Rev. 1988 Sep;4(6):543-69. doi: 10.1002/dmr.5610040602.

DOI:10.1002/dmr.5610040602
PMID:3065009
Abstract
摘要

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Insulin signaling requires glucose to promote lipid anabolism in adipocytes.胰岛素信号需要葡萄糖来促进脂肪细胞中的脂质合成。
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Mitochondrial oxidants, but not respiration, are sensitive to glucose in adipocytes.脂肪细胞中的线粒体氧化剂对葡萄糖敏感,但呼吸作用却不敏感。
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Lactate production is a prioritized feature of adipocyte metabolism.产乳酸是脂肪细胞代谢的优先特征。
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Insulin resistance in non-insulin-dependent diabetes mellitus. A review.非胰岛素依赖型糖尿病中的胰岛素抵抗。综述。
Acta Diabetol. 1996 Jul;33(2):87-99. doi: 10.1007/BF00569416.
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Insulin regulation of glucose and lipid metabolism in massive obesity.胰岛素对重度肥胖患者葡萄糖和脂质代谢的调节作用
Diabetologia. 1990 Apr;33(4):228-36. doi: 10.1007/BF00404801.
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Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity.葡萄糖转运蛋白的翻译前抑制导致非胰岛素依赖型糖尿病和肥胖患者脂肪细胞中的胰岛素抵抗。
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