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比较不同个体脂肪组织来源干细胞的生物学特性。

Comparing the biological characteristics of adipose tissue-derived stem cells of different persons.

机构信息

The Cardiology Department of Chinese PLA General Hospital, Fu Xin Road Number 28, Beijing, 100853, China.

出版信息

J Cell Biochem. 2012 Jun;113(6):2020-6. doi: 10.1002/jcb.24070.

Abstract

Scientists have found that cell sex is a variable that considerably influences the regeneration abilities of muscle-derived stem cells' in mice. We try to find out whether the cell sex or cell age (the age of donor) will influence the biological characteristics of human adipose tissue-derived stem cells (H-ADSCs). The results indicate that cell sex influences the proliferation, differentiation, paracrine, and anti-apoptosis abilities of the H-ADSCs, and cell age may also affect the H-ADSCs' differentiation and anti-apoptosis abilities.

摘要

科学家们发现,细胞性别是一个重要的变量,它极大地影响了肌肉源性干细胞在小鼠体内的再生能力。我们试图探究细胞性别或细胞年龄(供体的年龄)是否会影响人脂肪组织源性干细胞(H-ADSCs)的生物学特性。结果表明,细胞性别会影响 H-ADSCs 的增殖、分化、旁分泌和抗凋亡能力,而细胞年龄也可能影响 H-ADSCs 的分化和抗凋亡能力。

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