正电子发射断层成像术（PET）在肿瘤生长中的应用：并非看上去那么简单。
PET imaging of tumor growth: not as easy as it looks.
机构信息
Karmanos Cancer Institute, Department of Oncology, Wayne State University, Detroit, Michigan 48201-2013, USA.
出版信息
Clin Cancer Res. 2012 Mar 1;18(5):1189-91. doi: 10.1158/1078-0432.CCR-11-3198. Epub 2012 Jan 24.
Abstract
Positron emission tomography can be used to image tumor proliferation when combined with appropriate labeled tracers, such as the thymidine analog [(18)F]-3'-deoxy-3'-fluorothymidine. Although thymidine kinase 1 is the principal mechanism of cell trapping, other variables, such as the cellular level of native thymidine, may need to be considered.
摘要
正电子发射断层扫描（Positron emission tomography）可以与适当的标记示踪剂结合使用，用于成像肿瘤增殖，例如胸苷类似物[(18)F]-3'-脱氧-3'-氟胸苷。虽然胸苷激酶 1 是细胞捕获的主要机制，但还需要考虑其他变量，例如细胞内天然胸苷的水平。
相似文献
1
PET imaging of tumor growth: not as easy as it looks.正电子发射断层成像术（PET）在肿瘤生长中的应用：并非看上去那么简单。
Clin Cancer Res. 2012 Mar 1;18(5):1189-91. doi: 10.1158/1078-0432.CCR-11-3198. Epub 2012 Jan 24.
2
Preliminary F-MRS Study of Tumor Cell Proliferation with 3'-deoxy-3'-fluorothymidine and Its Metabolite (FLT-MP).3'-脱氧-3'-氟胸苷及其代谢物（FLT-MP）标记肿瘤细胞增殖的初步 F-MRS 研究。
Contrast Media Mol Imaging. 2017 Sep 26;2017:3981358. doi: 10.1155/2017/3981358. eCollection 2017.
3
Imaging colon cancer response following treatment with AZD1152: a preclinical analysis of [18F]fluoro-2-deoxyglucose and 3'-deoxy-3'-[18F]fluorothymidine imaging.评估 AZD1152 治疗后结肠癌反应的影像学研究：[18F]氟脱氧葡萄糖和 3'-去氧-3'-[18F]氟胸苷影像学分析的临床前研究。
Clin Cancer Res. 2011 Mar 1;17(5):1099-110. doi: 10.1158/1078-0432.CCR-10-1430. Epub 2011 Jan 18.
4
Variability of Proliferation and Diffusion in Different Lung Cancer Models as Measured by 3'-Deoxy-3'-¹⁸F-Fluorothymidine PET and Diffusion-Weighted MR Imaging.3'-脱氧-3'-¹⁸F-氟代胸苷 PET 和扩散加权磁共振成像测量的不同肺癌模型中的增殖和扩散的变异性。
J Nucl Med. 2014 Jun;55(6):983-8. doi: 10.2967/jnumed.113.133348. Epub 2014 Apr 28.
5
Depicting Changes in Tumor Biology in Response to Cetuximab Monotherapy or Combination Therapy by Apoptosis and Proliferation Imaging Using F-ICMT-11 and F-FLT PET.使用 F-ICMT-11 和 F-FLT PET 通过凋亡和增殖显像描绘西妥昔单抗单药或联合治疗对肿瘤生物学的影响变化。
J Nucl Med. 2018 Oct;59(10):1558-1565. doi: 10.2967/jnumed.118.209304. Epub 2018 May 24.
6
Early assessment of tumor response to JAC106, an anti-tubulin agent, by 3'-deoxy-3'-[¹⁸F]fluorothymidine in preclinical tumor models.通过 3'-脱氧-3'-[¹⁸F]氟胸苷在临床前肿瘤模型中对 JAC106（一种抗微管蛋白药物）的早期肿瘤反应评估。
Eur J Nucl Med Mol Imaging. 2011 Aug;38(8):1436-48. doi: 10.1007/s00259-011-1802-4. Epub 2011 Apr 12.
7
Biodistribution and uptake of 3'-deoxy-3'-fluorothymidine in ENT1-knockout mice and in an ENT1-knockdown tumor model.ENT1 基因敲除小鼠和 ENT1 基因敲低肿瘤模型中 3'-脱氧-3'-氟胸苷的分布和摄取。
J Nucl Med. 2010 Sep;51(9):1447-55. doi: 10.2967/jnumed.110.076356. Epub 2010 Aug 18.
8
PET imaging of proliferation with pyrimidines.正电子发射断层扫描技术（PET）成像中的嘧啶类增殖研究
J Nucl Med. 2013 Jun;54(6):903-12. doi: 10.2967/jnumed.112.112201. Epub 2013 May 14.
9
Molecular imaging of proliferation in vivo: positron emission tomography with [18F]fluorothymidine.体内增殖的分子成像：用[18F]氟代胸腺嘧啶核苷进行正电子发射断层扫描。
Methods. 2009 Jun;48(2):205-15. doi: 10.1016/j.ymeth.2009.03.009. Epub 2009 Mar 24.
10
Effects of capecitabine treatment on the uptake of thymidine analogs using exploratory PET imaging agents: F-FAU, F-FMAU, and F-FLT.使用探索性正电子发射断层扫描（PET）显像剂：氟代脱氧胸苷（F-FAU）、氟代甲基脱氧胸苷（F-FMAU）和氟代胸苷（F-FLT），研究卡培他滨治疗对胸苷类似物摄取的影响。
Cancer Imaging. 2016 Oct 17;16(1):34. doi: 10.1186/s40644-016-0092-2.
引用本文的文献
1
F-FLT PET/CT as a Prognostic Imaging Biomarker of Disease-Specific Survival in Patients with Primary Soft-Tissue Sarcoma.氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描作为原发性软组织肉瘤患者疾病特异性生存的预后成像生物标志物。
J Nucl Med. 2022 May;63(5):708-712. doi: 10.2967/jnumed.121.262502. Epub 2021 Sep 30.
2
STING-driven interferon signaling triggers metabolic alterations in pancreas cancer cells visualized by [F]FLT PET imaging.STING 驱动的干扰素信号转导通过 [F]FLT PET 成像观察到胰腺癌细胞的代谢改变。
Proc Natl Acad Sci U S A. 2021 Sep 7;118(36). doi: 10.1073/pnas.2105390118.
3
Glioma surveillance imaging: current strategies, shortcomings, challenges and outlook.胶质瘤的监测成像：当前策略、缺点、挑战与展望
BJR Open. 2020 Jun 23;2(1):20200009. doi: 10.1259/bjro.20200009. eCollection 2020.
4
Preclinical Applications of 3'-Deoxy-3'-[F]Fluorothymidine in Oncology - A Systematic Review.3'-脱氧-3'-[F]氟胸腺嘧啶在肿瘤学中的临床前应用——一项系统综述
Theranostics. 2017 Jan 1;7(1):40-50. doi: 10.7150/thno.16676. eCollection 2017.
5
Response Monitoring with [F]FLT PET and Diffusion-Weighted MRI After Cytotoxic 5-FU Treatment in an Experimental Rat Model for Colorectal Liver Metastases.在结直肠癌肝转移实验大鼠模型中，用[F]氟代胸苷正电子发射断层扫描（PET）和扩散加权磁共振成像（MRI）进行细胞毒性5-氟尿嘧啶治疗后的反应监测
Mol Imaging Biol. 2017 Aug;19(4):540-549. doi: 10.1007/s11307-016-1021-2.
6
Metabolic Imaging to Assess Treatment Response to Cytotoxic and Cytostatic Agents.代谢成像评估细胞毒性和细胞抑制药物的治疗反应
Front Oncol. 2016 Jul 15;6:152. doi: 10.3389/fonc.2016.00152. eCollection 2016.
7
¹⁸F-FLT and ¹⁸F-FDOPA PET kinetics in recurrent brain tumors.¹⁸F-FLT和¹⁸F-FDOPA在复发性脑肿瘤中的PET动力学
Eur J Nucl Med Mol Imaging. 2014 Jun;41(6):1199-209. doi: 10.1007/s00259-013-2678-2. Epub 2014 Mar 7.
8
Involvement of endoplasmic reticulum stress in capsaicin-induced apoptosis of human pancreatic cancer cells.内质网应激在辣椒素诱导人胰腺癌细胞凋亡中的作用。
Evid Based Complement Alternat Med. 2013;2013:629750. doi: 10.1155/2013/629750. Epub 2013 May 28.
9
Monitoring tumor response with radiolabeled nucleoside analogs in a hepatoma-bearing mouse model early after doxisome(®) treatment.在多西紫杉醇（®）治疗后早期荷肝癌小鼠模型中用放射性标记核苷类似物监测肿瘤反应。
Mol Imaging Biol. 2013 Jun;15(3):326-35. doi: 10.1007/s11307-012-0604-9.
本文引用的文献
1
[(18)F]FLT-PET imaging does not always "light up" proliferating tumor cells.（18）F]FLT-PET 成像并不总是能“点亮”增殖的肿瘤细胞。
Clin Cancer Res. 2012 Mar 1;18(5):1303-12. doi: 10.1158/1078-0432.CCR-11-1433. Epub 2011 Dec 14.
2
Early identification of antigen-specific immune responses in vivo by [18F]-labeled 3'-fluoro-3'-deoxy-thymidine ([18F]FLT) PET imaging.通过[18F]标记的 3'-氟-3'-脱氧胸苷([18F]FLT) PET 成像对体内抗原特异性免疫反应的早期识别。
Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18396-9. doi: 10.1073/pnas.1113045108. Epub 2011 Oct 24.
3
The role of nucleoside/nucleotide transport and metabolism in the uptake and retention of 3'-fluoro-3'-deoxythymidine in human B-lymphoblast cells.核苷/核苷酸转运和代谢在人 B 淋巴细胞摄取和保留 3'-氟-3'-脱氧胸苷中的作用。
Nucl Med Biol. 2011 Oct;38(7):979-86. doi: 10.1016/j.nucmedbio.2011.03.009. Epub 2011 Jun 22.
4
[18F]Fluorothymidine positron emission tomography before and 7 days after gefitinib treatment predicts response in patients with advanced adenocarcinoma of the lung.吉非替尼治疗前及治疗7天后的[18F]氟胸苷正电子发射断层扫描可预测晚期肺腺癌患者的反应。
Clin Cancer Res. 2008 Nov 15;14(22):7423-9. doi: 10.1158/1078-0432.CCR-08-0312.
5
Kinetic analysis of 3'-deoxy-3'-18F-fluorothymidine in patients with gliomas.胶质瘤患者中3'-脱氧-3'-18F-氟胸苷的动力学分析。
J Nucl Med. 2006 Oct;47(10):1612-21.
6
A simplified analysis of [18F]3'-deoxy-3'-fluorothymidine metabolism and retention.[18F]3'-脱氧-3'-氟胸腺嘧啶代谢与滞留的简化分析
Eur J Nucl Med Mol Imaging. 2005 Nov;32(11):1269-75. doi: 10.1007/s00259-005-1813-0. Epub 2005 Jul 1.
7
Rapid quantitation of plasma 2'-deoxyuridine by high-performance liquid chromatography/atmospheric pressure chemical ionization mass spectrometry and its application to pharmacodynamic studies in cancer patients.高效液相色谱/大气压化学电离质谱法快速定量测定血浆2'-脱氧尿苷及其在癌症患者药效学研究中的应用
J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Jun 5;820(1):121-30. doi: 10.1016/j.jchromb.2005.03.008. Epub 2005 Apr 19.
8
Imaging proliferation in lung tumors with PET: 18F-FLT versus 18F-FDG.利用正电子发射断层显像（PET）对肺肿瘤增殖进行成像：18F-氟代胸苷（18F-FLT）与18F-氟代脱氧葡萄糖（18F-FDG）的比较
J Nucl Med. 2003 Sep;44(9):1426-31.
9
2-[11C]thymidine positron emission tomography as an indicator of thymidylate synthase inhibition in patients treated with AG337.2-[11C]胸苷正电子发射断层扫描作为接受AG337治疗患者胸苷酸合成酶抑制的指标
J Natl Cancer Inst. 2003 May 7;95(9):675-82. doi: 10.1093/jnci/95.9.675.
10
Validation of FLT uptake as a measure of thymidine kinase-1 activity in A549 carcinoma cells.验证氟代胸苷摄取作为A549癌细胞中胸苷激酶-1活性的一种测量方法。
J Nucl Med. 2002 Sep;43(9):1210-7.
Zotero 插件