Abdul-Karim F W, Kida M, Wentz W B, Carter J R, Sorensen K, Macfee M, Zika J, Makley J T
Institute of Pathology, Department of Reproductive Biology, Case Western Reserve University, Cleveland, Ohio.
Gynecol Oncol. 1990 Nov;39(2):108-14. doi: 10.1016/0090-8258(90)90414-g.
Between 1948 and 1984, autopsies were performed on 305 patients with primary carcinomas of the cervix, endometrium, ovaries, fallopian tubes, vulva, and vagina. Skeletal metastases were detected premortem and at autopsy in 49 cases (16.1%): cervix, 20 (40.8%); endometrium, 17 (34.7%); ovary, 7 (14.3%); vulva, 4 (8.2%); fallopian tube, 1 (2%). There were no cases of osseous metastasis from vaginal carcinoma. The incidence and sites of metastasis from these gynecologic carcinomas were correlated with their clinical and histopathologic classifications. This clinicopathologic study, based on autopsy data, demonstrates that osseous metastases are not uncommon, are significantly greater than clinically appreciated, and correlate with advanced anatomic stage and histopathologic type and grade.
1948年至1984年间，对305例子宫颈、子宫内膜、卵巢、输卵管、外阴和阴道原发性癌患者进行了尸检。49例（16.1%）在死前和尸检时检测到骨骼转移：子宫颈，20例（40.8%）；子宫内膜，17例（34.7%）；卵巢，7例（14.3%）；外阴，4例（8.2%）；输卵管，1例（2%）。阴道癌无骨转移病例。这些妇科癌症转移的发生率和部位与其临床和组织病理学分类相关。这项基于尸检数据的临床病理研究表明，骨转移并不罕见，其发生率明显高于临床评估，且与解剖学分期、组织病理学类型和分级相关。
