Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing 100044, China.
Department of Orthopaedic Oncology, Peking University People's Hospital, Beijing 100044, China.
Int J Environ Res Public Health. 2022 Jun 2;19(11):6823. doi: 10.3390/ijerph19116823.
The aim of this study was to describe the clinicopathological features of endometrial cancer (EC) patients with bone metastases treated with surgery and to systematically review the literature.
We performed a retrospective study to include patients with bone metastases of EC at Peking University People's Hospital from 2000 to 2019. Clinicopathological features and survival outcomes were collected.
Among the 1662 patients with EC, 14 (0.84%) were identified with bone metastases, and all were treated surgically. Thirteen cases were analyzed. Four had bone metastases when diagnosed, and the remaining nine cases had bone metastases when first relapsed, with a median time to recurrence of 13 months (range, 5-144). The median age of the 13 patients was 58 years old (range, 45-76). Twelve were endometrioid carcinoma. The majority of sites of bone metastases were the pelvis, followed by the spine. The median overall survival (OS) was 57 months. We further combined the 13 patients with another 24 cases identified from literature research. There was no significant difference in clinicopathological characteristics between the patients with bone metastases when diagnosed and when they first relapsed. The median OS was numerically longer for patients with bone metastases when diagnosed than when they first relapsed (57 vs. 36 months, = 0.084).
Patients with bone metastases of EC might benefit from comprehensive treatment based on surgery, as symptoms can be palliated and survival can probably be extended.
本研究旨在描述接受手术治疗的子宫内膜癌（EC）骨转移患者的临床病理特征，并对相关文献进行系统回顾。
我们进行了一项回顾性研究，纳入 2000 年至 2019 年期间在北京大学人民医院就诊的 EC 伴骨转移患者。收集了患者的临床病理特征和生存结局。
在 1662 例 EC 患者中，有 14 例（0.84%）发生骨转移，均接受了手术治疗。分析了其中的 13 例患者。其中 4 例在诊断时即发生骨转移，9 例在首次复发时发生骨转移，中位复发时间为 13 个月（范围，5-144）。13 例患者的中位年龄为 58 岁（范围，45-76）。12 例为子宫内膜样癌。骨转移的大多数部位是骨盆，其次是脊柱。中位总生存（OS）为 57 个月。我们进一步将这 13 例患者与文献研究中另外 24 例患者进行了汇总。在诊断时和首次复发时发生骨转移的患者在临床病理特征方面无显著差异。诊断时发生骨转移的患者的中位 OS 长于首次复发时（57 比 36 个月， = 0.084）。
对于 EC 伴骨转移的患者，基于手术的综合治疗可能有益，可以缓解症状并可能延长生存。
