尼日利亚扎里亚地区胃癌的管理与治疗结果
Management and outcome of gastric carcinoma in Zaria, Nigeria.
作者信息
Ahmed A, Ukwenya A Y, Makama J G, Mohammad I
机构信息
Division of General Surgery, Department of Surgery, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.
出版信息
Afr Health Sci. 2011 Sep;11(3):353-61.
INTRODUCTION
Gastric cancer is the second leading cause of cancer death in the world. The objective of this study was to present the clinical evaluation, treatment and outcome of 179 patients with gastric carcinoma in Zaria, Nigeria.
METHODS
Patients managed for histologically diagnosed gastric carcinoma were reviewed. The extent of surgical intervention was based on pre-operative and intra-operative staging balanced against the age and overall fitness of the patient. Mortality, morbidity and patient's survival were monitored.
RESULTS
There were 179 patients, with a male to female ratio of 1.4:1. Their mean age was 51 ± 6.3. Ten (5.6%) patients presented with early gastric cancer. Overall, 155(86.6%) patients had surgical intervention including gastric resection in 87 (56.1%). Of the gastrectomies , 28.7% were curative (R0). Postoperative complications were seen in 43(27.7%) patients. Postoperative mortality in 25(16.1%) patients was significantly associated with peritoneal metastasis (p<0.001), preoperative comorbidity (p<0.01) and age more than 60 years (p<0.03). The overall median survival was 13.6 months while 70.1% and 21.8% of patients that underwent gastrectomy survived for 1 and 5 years respectively.
CONCLUSION
Treatment of gastric cancer should be based on a reasonable choice of operation that must consider not only the survival benefits but also the surgical risks and postoperative quality of life.
引言
胃癌是全球癌症死亡的第二大主要原因。本研究的目的是介绍尼日利亚扎里亚179例胃癌患者的临床评估、治疗及结果。
方法
对经组织学诊断为胃癌的患者进行回顾性研究。手术干预的范围基于术前和术中分期，并综合考虑患者的年龄和总体健康状况。监测死亡率、发病率和患者生存率。
结果
共有179例患者，男女比例为1.4:1。他们的平均年龄为51±6.3岁。10例（5.6%）患者为早期胃癌。总体而言，155例（86.6%）患者接受了手术干预，其中87例（56.1%）进行了胃切除术。在胃切除术中，28.7%为根治性切除（R0）。43例（27.7%）患者出现术后并发症。25例（16.1%）患者术后死亡与腹膜转移（p<0.001）、术前合并症（p<0.01）及年龄超过60岁（p<0.03）显著相关。总体中位生存期为13.6个月，接受胃切除术的患者中，70.1%和21.8%分别存活1年和5年。
结论
胃癌治疗应基于合理的手术选择，不仅要考虑生存获益，还要考虑手术风险和术后生活质量。
Zotero 插件