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Post-genomic clinical trials: the perspective of ACGT.

作者信息

Graf N, Desmedt C, Buffa F, Kafetzopoulos D, Forgó N, Kollek R, Hoppe A, Stamatakos G, Tsiknakis M

机构信息

University Hospital of Saarland Paediatric Haematology and Oncology, D-66421 Homburg, Germany.

出版信息

Ecancermedicalscience. 2008;2:66. doi: 10.3332/eCMS.2008.66. Epub 2008 Jan 21.

DOI:10.3332/eCMS.2008.66
PMID:22275963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3234044/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b5/3234044/ee48a3ce9568/can-2-66f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b5/3234044/5ecc5f9596b1/can-2-66f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b5/3234044/7c3e532939da/can-2-66f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b5/3234044/ee48a3ce9568/can-2-66f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b5/3234044/5ecc5f9596b1/can-2-66f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b5/3234044/7c3e532939da/can-2-66f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b5/3234044/ee48a3ce9568/can-2-66f3.jpg

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The "Oncosimulator": a multilevel, clinically oriented simulation system of tumor growth and organism response to therapeutic schemes. Towards the clinical evaluation of in silico oncology.“肿瘤模拟器”:一个多层次、面向临床的肿瘤生长及机体对治疗方案反应的模拟系统。迈向计算机肿瘤学的临床评估。
Annu Int Conf IEEE Eng Med Biol Soc. 2007;2007:6629-32. doi: 10.1109/IEMBS.2007.4353879.
2
Characterization of protein-interaction networks in tumors.肿瘤中蛋白质相互作用网络的表征
BMC Bioinformatics. 2007 Jun 27;8:224. doi: 10.1186/1471-2105-8-224.
3
Taking gene-expression profiling to the clinic: when will molecular signatures become relevant to patient care?
将基因表达谱分析应用于临床:分子特征何时会与患者护理相关?
Nat Rev Cancer. 2007 Jul;7(7):545-53. doi: 10.1038/nrc2173.
4
Network analysis approach for biology.生物学的网络分析方法。
Cell Mol Life Sci. 2007 Jul;64(14):1739-51. doi: 10.1007/s00018-007-7053-7.
5
Cancer systems biology: exploring cancer-associated genes on cellular networks.癌症系统生物学:在细胞网络上探索癌症相关基因。
Cell Mol Life Sci. 2007 Jul;64(14):1752-62. doi: 10.1007/s00018-007-7054-6.
6
Microarrays Technologies 2006: an overview.2006年微阵列技术综述
Pharmacogenomics. 2006 Dec;7(8):1153-8. doi: 10.2217/14622416.7.8.1153.
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The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements.微阵列质量控制(MAQC)项目展示了基因表达测量在不同平台间和同一平台内的可重复性。
Nat Biotechnol. 2006 Sep;24(9):1151-61. doi: 10.1038/nbt1239.
8
Discovering disease-genes by topological features in human protein-protein interaction network.通过人类蛋白质-蛋白质相互作用网络中的拓扑特征发现疾病基因。
Bioinformatics. 2006 Nov 15;22(22):2800-5. doi: 10.1093/bioinformatics/btl467. Epub 2006 Sep 5.
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A spatiotemporal, patient individualized simulation model of solid tumor response to chemotherapy in vivo: the paradigm of glioblastoma multiforme treated by temozolomide.实体瘤体内化疗反应的时空个体化模拟模型:多形性胶质母细胞瘤替莫唑胺治疗范例
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Cancer. 2006 Sep 15;107(6):1419-20; author reply 1420. doi: 10.1002/cncr.22140.