Macis D, Cazzaniga M, De Censi A, Bonanni B
Division of Cancer Prevention and Genetics, European Institute of Oncology, via Ripamonti 435, 20141 Milan, Italy.
Ecancermedicalscience. 2009;3:157. doi: 10.3332/ecancer.2009.157. Epub 2009 Oct 29.
In recent decades, several biomarkers have been investigated as predictors of breast cancer risk, development, prognosis and treatment efficacy.The detection of biomarkers strongly associated with breast carcinogenesis has an enormous potential, especially for selecting subjects at high risk of developing breast cancer who could benefit from chemopreventive treatments.Although the number of potential biomarkers continues to increase, a unique biomarker for breast cancer risk prediction has not been identified and it is probable that a panel of biomarkers will prove optimal. Further studies are needed to validate breast cancer biomarkers evaluation for individual risk assessment.This review summarizes the main biomarkers, which are important at different stages of breast carcinogenesis with updates from the recent literature.
近几十年来，人们对几种生物标志物进行了研究，将其作为乳腺癌风险、发展、预后和治疗效果的预测指标。检测与乳腺癌发生密切相关的生物标志物具有巨大潜力，特别是对于筛选出可能从化学预防治疗中获益的乳腺癌高危人群。尽管潜在生物标志物的数量不断增加，但尚未确定一种用于预测乳腺癌风险的独特生物标志物，一组生物标志物可能被证明是最佳的。需要进一步研究来验证用于个体风险评估的乳腺癌生物标志物评估。本综述总结了主要的生物标志物，这些生物标志物在乳腺癌发生的不同阶段都很重要，并结合了近期文献的更新内容。
