Hammarström M, Marsk L
Department of Obstetrics and Gynecology, Karolinska Hospital, Stockholm, Sweden.
Gynecol Obstet Invest. 1990;30(1):19-22. doi: 10.1159/000293205.
A consecutive series of 224 women undergoing transcervical chorionic villi sampling (CVS) were analyzed for the presence of cervical microbes. The outcome of pregnancy was related to age, number of aspirations and to the presence or not of microbes. The CVS group was compared to a group of 200 women with live fetuses at 8-11 weeks of gestation not undergoing CVS (ultrasound, US group). In the US group the miscarriage rate was 8.5% with 5.9% occurring after the 16th week of gestation. In the CVS group 20.3% ended as a miscarriage, 28.9% of these after the 16th week. There was no correlation between miscarriage rate and maternal age in the US group. In the CVS group younger women had a prominent rate of fetal loss. In the present study the risk of fetal loss after CVS was associated with a previous history of spontaneous abortions, with several aspirations performed, and with bacterial colonization of the cervix--candida and gardnerella excluded.
对连续224例行经宫颈绒毛取样（CVS）的女性进行了宫颈微生物检测分析。妊娠结局与年龄、取样次数以及是否存在微生物有关。将CVS组与200名妊娠8 - 11周有活胎且未行CVS的女性（超声检查，US组）进行比较。US组的流产率为8.5%，其中5.9%发生在妊娠16周之后。CVS组中20.3%以流产告终，其中28.9%发生在妊娠16周之后。US组中流产率与产妇年龄无关。在CVS组中，年轻女性的胎儿丢失率较高。在本研究中，CVS后胎儿丢失的风险与既往自然流产史、多次取样以及宫颈细菌定植有关（不包括念珠菌和加德纳菌）。
