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神经细胞黏附分子（NCAM）与成纤维细胞生长因子受体（FGFR）信号传导之间的相互作用是卵巢癌进展的基础。

The interplay between NCAM and FGFR signalling underlies ovarian cancer progression.

作者信息

Colombo N, Cavallaro U

机构信息

Department of Gynaecological Oncology (NC), and Molecular Medicine Program (UC), European Institute of Oncology, Milano, Italy.

出版信息

Ecancermedicalscience. 2011;5:226. doi: 10.3332/ecancer.2011.226. Epub 2011 Oct 20.

DOI:10.3332/ecancer.2011.226
PMID:22276065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3223954/
Abstract

Epithelial ovarian carcinoma (EOC) is an aggressive neoplasm, which has often disseminated to peritoneal cavity at the time of diagnosis. In order to better understand the molecular mechanisms behind EOC progression, we investigated the expression and functional role of neural cell adhesion molecule (NCAM) in this tumour type.

摘要

上皮性卵巢癌（EOC）是一种侵袭性肿瘤，在诊断时往往已扩散至腹腔。为了更好地了解EOC进展背后的分子机制，我们研究了神经细胞黏附分子（NCAM）在这种肿瘤类型中的表达及功能作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7603/3223954/930e880eebee/ecancer226F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7603/3223954/930e880eebee/ecancer226F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7603/3223954/930e880eebee/ecancer226F1.jpg

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本文引用的文献

1
The adhesion molecule NCAM promotes ovarian cancer progression via FGFR signalling.黏附分子 NCAM 通过 FGFR 信号促进卵巢癌进展。
EMBO Mol Med. 2011 Aug;3(8):480-94. doi: 10.1002/emmm.201100152. Epub 2011 Jul 8.
2
The binding of NCAM to FGFR1 induces a specific cellular response mediated by receptor trafficking.NCAM 与 FGFR1 的结合诱导由受体运输介导的特定细胞反应。
J Cell Biol. 2009 Dec 28;187(7):1101-16. doi: 10.1083/jcb.200903030.
3
Neural cell adhesion molecule regulates the cellular response to fibroblast growth factor.
PLoS One. 2018 Nov 1;13(11):e0206786. doi: 10.1371/journal.pone.0206786. eCollection 2018.
神经细胞黏附分子调节细胞对成纤维细胞生长因子的反应。
J Cell Sci. 2007 Dec 15;120(Pt 24):4388-94. doi: 10.1242/jcs.010744. Epub 2007 Nov 27.