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[酒精的致心律失常作用]

[Arrhythmogenic effects of alcohol].

作者信息

Krasniqi A, Bostaca I, Dima-Cosma Corina, Crişu Daniela, Aursulesei Viviana

机构信息

Centrul Clinic Universitar Prishtine, Kosovo.

出版信息

Rev Med Chir Soc Med Nat Iasi. 2011 Oct-Dec;115(4):1052-6.

PMID:22276445
Abstract

UNLABELLED

Acute or chronic excessive consumption of alcohol can cause cardiac arrhythmias, particularly supraventricular tachyarrhythmias. Experimental and clinical data show that chronic excessive alcohol ingestion has a destructive role on cardiac tissue, which significantly deteriorates the rhythm and contractile activity, manifested by the appearance of cardiac arrythmias and dilated cardiomyopathy.

AIM

The aim of this study was to evaluate and analyze the ECG changes and disturbances of cardiac rhythm and conduction in patients after an acute or chronic excessive consumption of alcohol.

MATERIAL AND METHODS

The study included 187 patients (184 males and 3 females). Each patient followed biochemical and hematological analysis as well as paraclinical investigation measurements.

RESULTS

The most common types of arrhythmia were permanent atrial fibrillation (61%). Paroxysmal atrial fibrillation and supraventricular extrasystoles were found in patients without significant echocardiographic deteriorations. These arrhythmias appeared after an excessive alcohol drinking and paroxysmal atrial fibrillation was converted to normal sinus rhythm after a short period of abstinence or after pharmacologic therapy. Ventricular arrhythmias (ventricular extrasystoles, non-sustained ventricular tachycardia-4.7%, torsada de point-1.5%) were less frequent. Conduction disturbance (left bundle branch-LBBB 6.3%, right bundle branch-RBBB 10%) were found in patients who had a history of consuming >150 g/day of alcohol for >10 years, with dilated heart chambers and systolic ventricular function much more deteriorated (symptomatic stage of heart failure).

CONCLUSION

Excessive alcohol consumption may lead to cardiac arrhythmias in patients with existing heart disease as well as in healthy individuals.

摘要

未标注

急性或慢性过量饮酒可导致心律失常,尤其是室上性快速心律失常。实验和临床数据表明,慢性过量饮酒对心脏组织具有破坏作用,会显著恶化心律和收缩活动,表现为心律失常和扩张型心肌病。

目的

本研究旨在评估和分析急性或慢性过量饮酒患者的心电图变化以及心律和传导紊乱情况。

材料与方法

该研究纳入了187例患者(184例男性和3例女性)。每位患者均接受了生化和血液学分析以及辅助临床检查测量。

结果

最常见的心律失常类型是永久性心房颤动(61%)。阵发性心房颤动和室上性早搏见于超声心动图无明显恶化的患者。这些心律失常在过量饮酒后出现,阵发性心房颤动在短期戒酒或药物治疗后可转为正常窦性心律。室性心律失常(室性早搏、非持续性室性心动过速 - 4.7%,尖端扭转型室速 - 1.5%)较少见。传导障碍(左束支传导阻滞 - LBBB 6.3%,右束支传导阻滞 - RBBB 10%)见于有每日饮酒>150克超过10年病史、心腔扩大且心室收缩功能严重恶化(心力衰竭症状期)的患者。

结论

过量饮酒可能导致现有心脏病患者以及健康个体出现心律失常。

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1
[Arrhythmogenic effects of alcohol].[酒精的致心律失常作用]
Rev Med Chir Soc Med Nat Iasi. 2011 Oct-Dec;115(4):1052-6.
2
Effects of alcohol on atrial fibrillation: myths and truths.酒精对心房颤动的影响:误解与真相。
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Arch Mal Coeur Vaiss. 1990 Jan;83(1):15-21.
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[Arrhythmia-induced dilated cardiomyopathies].[心律失常性扩张型心肌病]
Bull Acad Natl Med. 2006 Jun;190(6):1225-35; discussion 1235-6.
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Ventricular tachycardia with QRS configuration similar to that in sinus rhythm and a myocardial origin: differential diagnosis with bundle branch reentry.QRS形态与窦性心律相似且起源于心肌的室性心动过速:与束支折返性心动过速的鉴别诊断
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Heart rate variability in patients suffering from structural heart disease and decreased AV-nodal conduction capacity. Insights into the formation of heart rate variability.患有结构性心脏病且房室结传导能力下降患者的心率变异性。对心率变异性形成的见解。
Z Kardiol. 2004 Mar;93(3):229-33. doi: 10.1007/s00392-004-0050-z.

引用本文的文献

1
Alcoholic Cardiomyopathy: Multigenic Changes Underlie Cardiovascular Dysfunction.酒精性心肌病:多基因变化是心血管功能障碍的基础。
J Cardiol Clin Res. 2014 Jan-Mar;2(1). Epub 2014 Jan 24.