Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
J Am Chem Soc. 2012 Feb 8;134(5):2547-50. doi: 10.1021/ja212020b. Epub 2012 Jan 27.
Intermolecular Ritter-type C-H amination of unactivated sp(3) carbons has been developed. This new reaction proceeds under mild conditions using readily available reagents and an inexpensive source of nitrogen (acetonitrile). A broad scope of substrates can be aminated with this method since many functional groups are tolerated. This reaction also allows for the direct, innate C-H amination of a variety of hydrocarbons such as cyclohexane without the need of prefunctionalization or installation of a directing group.
发展了一种非活化 sp(3)碳的分子间里特型 C-H 胺化反应。该新反应在温和条件下进行,使用易得的试剂和廉价的氮源(乙腈)。由于许多官能团可以被容忍,因此该方法可以对广泛的底物进行胺化。该反应还允许各种烃类如环己烷的直接、固有 C-H 胺化,而无需预官能化或安装导向基团。