Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Angew Chem Int Ed Engl. 2011 Sep 5;50(37):8647-51. doi: 10.1002/anie.201102880. Epub 2011 Aug 2.
[Image: see text] The Pd(0)-catalyzed intermolecular C–H amination of unactivated C(sp)–H bonds using aryl amines as the nitrogen source is disclosed. Either the C–N cross-coupling product or the C–H amination product could be accessed selectively by adjusting the steric environment of the substrate.
图中展示了 Pd(0)催化的未活化 C(sp)–H 键与芳胺作为氮源的分子间 C–H 胺化反应。通过调节底物的空间环境,可以选择性地得到 C–N 交叉偶联产物或 C–H 胺化产物。