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产前护理、胎儿生长发育欠佳的识别与晚期死产风险:奥克兰死产研究的结果

Antenatal care, identification of suboptimal fetal growth and risk of late stillbirth: findings from the Auckland Stillbirth Study.

作者信息

Stacey Tomasina, Thompson John M D, Mitchell Edwin A, Zuccollo Jane M, Ekeroma Alec J, McCowan Lesley M E

机构信息

Department of Obstetrics and Gynaecology, University of Auckland, Grafton, Auckland, New Zealand.

出版信息

Aust N Z J Obstet Gynaecol. 2012 Jun;52(3):242-7. doi: 10.1111/j.1479-828X.2011.01406.x. Epub 2012 Jan 25.

Abstract

INTRODUCTION

Stillbirth remains an important public health problem in Australia and New Zealand. The role that antenatal care plays in the prevention of stillbirth in high-income countries is unclear.

METHODS

Cases were women with a singleton, late stillbirth without congenital abnormality, booked to deliver in the Auckland region and born between July 2006 and June 2009. Two controls with ongoing pregnancies were randomly selected at the same gestation at which the stillbirth occurred. Data were collected through interview-administered questionnaires and from antenatal records.

RESULTS

One hundred and fifty five of 215 (72%) cases and 310 of 429 (72%) controls consented to take part in the study. Accessing <50% of recommended antenatal visits was associated with a more than twofold increase in late stillbirth (adjusted odds ratio, aOR, 2.68; 95% CI, 1.04-6.90) compared with accessing the recommended number of visits. Small-for-gestational-age (SGA) babies that had not been identified as SGA prior to birth were significantly more at risk of being stillborn (aOR, 9.46; 95% CI, 1.98-45.13) compared with SGA babies that were identified as such in the antenatal period. No relationship was found between type or model of maternity care provider at booking and late stillbirth risk.

DISCUSSION

This study reinforces the importance of regular antenatal care attendance. Identification of SGA may be one way by which antenatal care reduces stillbirth.

摘要

引言

死产在澳大利亚和新西兰仍然是一个重要的公共卫生问题。在高收入国家,产前护理在预防死产方面所起的作用尚不清楚。

方法

研究对象为2006年7月至2009年6月期间在奥克兰地区登记分娩、单胎、晚期死产且无先天性异常的妇女。在死产发生时的相同孕周,随机选取两名正在怀孕的对照者。通过访谈问卷和产前记录收集数据。

结果

215例病例中有155例(72%)、429例对照者中有310例(72%)同意参与研究。与接受推荐次数的产前检查相比,接受少于50%推荐产前检查次数的孕妇晚期死产风险增加两倍多(调整后的优势比,aOR,2.68;95%置信区间,1.04 - 6.90)。与产前被确定为小于胎龄(SGA)的婴儿相比,出生前未被确定为SGA的SGA婴儿死产风险显著更高(aOR,9.46;95%置信区间,1.98 - 45.13)。未发现预约时的产科护理提供者类型或模式与晚期死产风险之间存在关联。

讨论

本研究强化了定期参加产前护理的重要性。识别SGA可能是产前护理降低死产风险的一种方式。

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