[1,5]-阴离子接力/[2,3]-Wittig 重排 3,3-双(硅基)烯丙基烯醇醚：有用的乙烯基双(硅烷)物种的合成。

[1,5]-Anion relay/[2,3]-Wittig rearrangement of 3,3-bis(silyl) allyl enol ethers: synthesis of useful vinyl bis(silane) species.

机构信息

Key Laboratory of Drug-Targeting of Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, P. R. China.

出版信息

Org Lett. 2012 Feb 17;14(4):1094-7. doi: 10.1021/ol300004b. Epub 2012 Jan 25.

DOI:10.1021/ol300004b

PMID:22276938

Abstract

The [1,5]-anion relay/[2,3]-Wittig rearrangement of 3,3-bis(silyl) enol allyl ethers has been developed. This reaction provides an efficient method to synthesize versatile vinyl bissilanes, which can be transformed into trisubstituted vinylsilanes through a [1,4]-Brook rearrangement/alkylation protocol using a wide range of electrophiles.

摘要

[1,5]-阴离子接力/[2,3]-Wittig 重排反应已被应用于 3,3-双（硅基）烯醇烯丙基醚中。此反应为合成多功能乙烯基双硅烷提供了有效的方法，通过[1,4]-Brook 重排/烷基化反应方案，使用广泛的亲电试剂，可以将其转化为三取代乙烯基硅烷。