人类巨细胞病毒引起的系统性红斑狼疮自身免疫。
Autoimmunity induced by human cytomegalovirus in patients with systemic lupus erythematosus.
出版信息
Arthritis Res Ther. 2012 Jan 23;14(1):101. doi: 10.1186/ar3525.
Abstract
Human cytomegalovirus is a common herpesvirus that is linked to autoimmunity, especially in genetically predisposed persons. The article by Hsieh and colleagues in a previous issue of suggests that a C-terminal peptide of the human cytomegalovirus protein pp65 is highly immunogenic in patients with systemic lupus erythematosus and that antibodies against this peptide cross-react with nuclear proteins and double-stranded DNA, which are highly frequent autoantibodies in systemic lupus erythematosus patients. These observations highlight the fact that immunization with one small cytomegalovirus-specific peptide results in multiple autoreactive antibodies, probably through molecular mimicry and epitope spreading, in genetically predisposed persons.
摘要
人巨细胞病毒是一种常见的疱疹病毒，与自身免疫有关，特别是在遗传易感性个体中。Hsieh 及其同事在之前一期的文章中提出，人巨细胞病毒蛋白 pp65 的 C 末端肽在系统性红斑狼疮患者中具有高度免疫原性，并且针对该肽的抗体与核蛋白和双链 DNA 发生交叉反应，这些核蛋白和双链 DNA 是系统性红斑狼疮患者中高度常见的自身抗体。这些观察结果强调了一个事实，即通过分子模拟和表位扩展，用一种小的巨细胞病毒特异性肽进行免疫接种会导致遗传易感性个体中产生多种自身反应性抗体。
相似文献
1
Autoimmunity induced by human cytomegalovirus in patients with systemic lupus erythematosus.人类巨细胞病毒引起的系统性红斑狼疮自身免疫。
Arthritis Res Ther. 2012 Jan 23;14(1):101. doi: 10.1186/ar3525.
2
Response to 'Fragment of tegument protein pp65 of human cytomegalovirus induces autoantibodies in BALB/c mice'.对“人巨细胞病毒被膜蛋白pp65片段诱导BALB/c小鼠产生自身抗体”的回应
Arthritis Res Ther. 2012 Sep 10;14(5):404. doi: 10.1186/ar4023.
3
Fragment of tegument protein pp65 of human cytomegalovirus induces autoantibodies in BALB/c mice.人巨细胞病毒衣壳蛋白 pp65 片段诱导 BALB/c 小鼠产生自身抗体。
Arthritis Res Ther. 2011;13(5):R162. doi: 10.1186/ar3481. Epub 2011 Oct 11.
4
Cytomegalovirus antigenemia assay: identification of the viral antigen as the lower matrix protein pp65.
J Infect Dis. 1992 Sep;166(3):683-4. doi: 10.1093/infdis/166.3.683.
5
Reactivation of cytomegalovirus in critically sick patients.危重症患者巨细胞病毒的再激活
Isr Med Assoc J. 2006 Aug;8(8):583-4.
6
Detection and quantification of cytomegalovirus in bone marrow transplant recipients by real time PCR and pp65 antigenemia.
Saudi Med J. 2008 Nov;29(11):1673-5.
7
[The use of flow cytometry in detecting CMV-PP65 antigenemia for the diagnosis of CMV hepatitis].
Zhonghua Gan Zang Bing Za Zhi. 2006 Apr;14(4):310-1.
8
Interest of quantitative pp65 cytomegalovirus antigenemia assay for human immunodeficiency virus-positive patients.定量 pp65 巨细胞病毒抗原血症检测对人类免疫缺陷病毒阳性患者的意义。
J Clin Microbiol. 1996 Dec;34(12):3255-6. doi: 10.1128/jcm.34.12.3255-3256.1996.
9
Leukocyte concentration in the performance of the pp65 antigenemia assay.pp65抗原血症检测中白细胞浓度
J Clin Microbiol. 2000 Aug;38(8):3137-8. doi: 10.1128/JCM.38.8.3137-3138.2000.
10
[The antigenemia test for cytomegalovirus].[巨细胞病毒抗原血症检测]
Enferm Infecc Microbiol Clin. 1994 May;12(5):251-61.
引用本文的文献
1
Hyperacute reactivation of cytomegalovirus-induced gastroduodenitis during remission induction in a young male patient with granulomatosis with polyangiitis: a case report and review of literature.一名患有肉芽肿性多血管炎的年轻男性患者在缓解诱导期巨细胞病毒引起的胃十二指肠炎症的超急性再激活：病例报告及文献复习
J Med Case Rep. 2025 Feb 24;19(1):68. doi: 10.1186/s13256-025-05103-7.
2
LASSO-derived nomogram for early identification of pediatric monogenic lupus.LASSO 衍生列线图用于早期识别儿科单基因狼疮。
World J Pediatr. 2024 Nov;20(11):1155-1167. doi: 10.1007/s12519-024-00817-y. Epub 2024 Jul 6.
3
Clinical phenotypes and prognosis of cytomegalovirus infection in the pediatric systemic lupus erythematosus: a longitudinal analysis.儿童系统性红斑狼疮中巨细胞病毒感染的临床表型和预后：一项纵向分析。
Pediatr Rheumatol Online J. 2023 Mar 16;21(1):25. doi: 10.1186/s12969-023-00807-w.
4
Lupus Cardiomyopathy and Nephritis Associated With Adalimumab and Cytomegalovirus Infection in a Patient With Seronegative Rheumatoid Arthritis: A Case of Rhupus Syndrome.血清阴性类风湿关节炎患者中与阿达木单抗和巨细胞病毒感染相关的狼疮性心肌病和肾炎：一例rhupus综合征病例
Cureus. 2023 Feb 1;15(2):e34489. doi: 10.7759/cureus.34489. eCollection 2023 Feb.
5
Do common infections trigger disease-onset or -severity in CTLA-4 insufficiency?常见感染是否会引发 CTLA-4 缺陷相关疾病的发病或严重程度？
Front Immunol. 2022 Nov 2;13:1011646. doi: 10.3389/fimmu.2022.1011646. eCollection 2022.
6
Association between lymphocyte subsets and cytomegalovirus infection status among patients with systemic lupus erythematosus: A pilot study.系统性红斑狼疮患者淋巴细胞亚群与巨细胞病毒感染状态的相关性：一项初步研究。
Medicine (Baltimore). 2019 Sep;98(39):e16997. doi: 10.1097/MD.0000000000016997.
7
Cytomegalovirus antigenemia in patients with autoimmune and non-autoimmune diseases in Beijing: A 10-year single hospital experience.北京地区自身免疫性和非自身免疫性疾病患者的巨细胞病毒抗原血症：一项 10 年单中心经验。
PLoS One. 2019 Aug 28;14(8):e0221793. doi: 10.1371/journal.pone.0221793. eCollection 2019.
8
Evaluation of EBV- and HCMV-Specific T Cell Responses in Systemic Lupus Erythematosus (SLE) Patients Using a Normalized Enzyme-Linked Immunospot (ELISPOT) Assay.采用酶联免疫斑点（ELISPOT）法评估系统性红斑狼疮（SLE）患者的 EBV 和 HCMV 特异性 T 细胞反应。
J Immunol Res. 2019 Feb 17;2019:4236503. doi: 10.1155/2019/4236503. eCollection 2019.
9
"Multi-Omics" Analyses of the Development and Function of Natural Killer Cells.自然杀伤细胞发育与功能的“多组学”分析
Front Immunol. 2017 Sep 5;8:1095. doi: 10.3389/fimmu.2017.01095. eCollection 2017.
10
Expansions of Cytotoxic CD4CD28 T Cells Drive Excess Cardiovascular Mortality in Rheumatoid Arthritis and Other Chronic Inflammatory Conditions and Are Triggered by CMV Infection.细胞毒性CD4CD28 T细胞的扩增导致类风湿关节炎和其他慢性炎症性疾病中过多的心血管死亡率，并由巨细胞病毒感染引发。
Front Immunol. 2017 Mar 2;8:195. doi: 10.3389/fimmu.2017.00195. eCollection 2017.
本文引用的文献
1
Fragment of tegument protein pp65 of human cytomegalovirus induces autoantibodies in BALB/c mice.人巨细胞病毒衣壳蛋白 pp65 片段诱导 BALB/c 小鼠产生自身抗体。
Arthritis Res Ther. 2011;13(5):R162. doi: 10.1186/ar3481. Epub 2011 Oct 11.
2
Cytomegalovirus-induced immunopathology and its clinical consequences.巨细胞病毒诱导的免疫病理学及其临床后果。
Herpesviridae. 2011 Apr 7;2(1):6. doi: 10.1186/2042-4280-2-6.
3
The L412F variant of Toll-like receptor 3 (TLR3) is associated with cutaneous candidiasis, increased susceptibility to cytomegalovirus, and autoimmunity.Toll样受体3（TLR3）的L412F变体与皮肤念珠菌病、对巨细胞病毒易感性增加以及自身免疫有关。
J Allergy Clin Immunol. 2011 Feb;127(2):528-31. doi: 10.1016/j.jaci.2010.09.031. Epub 2010 Nov 18.
4
HCMV-encoded chemokine receptor US28 mediates proliferative signaling through the IL-6-STAT3 axis.巨细胞病毒编码趋化因子受体 US28 通过 IL-6-STAT3 轴介导增殖信号。
Sci Signal. 2010 Aug 3;3(133):ra58. doi: 10.1126/scisignal.2001180.
5
Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus.狼疮中抗核酸和类风湿因子自身抗体的产生需要内体Toll样受体信号传导。
Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12061-6. doi: 10.1073/pnas.0905441106. Epub 2009 Jul 2.
6
Generalized Wegener's granulomatosis in an immunocompetent adult after cytomegalovirus mononucleosis and bacterial urinary tract infection.
Arthritis Rheum. 2009 May;60(5):1558-62. doi: 10.1002/art.24487.
7
Cutting edge: Overlapping functions of TLR7 and TLR9 for innate defense against a herpesvirus infection.前沿：Toll样受体7（TLR7）和Toll样受体9（TLR9）在针对疱疹病毒感染的天然免疫防御中的重叠功能
J Immunol. 2008 May 1;180(9):5799-803. doi: 10.4049/jimmunol.180.9.5799.
8
Human CMV infection induces 5-lipoxygenase expression and leukotriene B4 production in vascular smooth muscle cells.人巨细胞病毒感染可诱导血管平滑肌细胞中5-脂氧合酶的表达及白三烯B4的产生。
J Exp Med. 2008 Jan 21;205(1):19-24. doi: 10.1084/jem.20070201. Epub 2008 Jan 7.
9
Human cytomegalovirus differentially controls B cell and T cell responses through effects on plasmacytoid dendritic cells.人巨细胞病毒通过对浆细胞样树突状细胞的影响来差异调控B细胞和T细胞反应。
J Immunol. 2007 Dec 1;179(11):7767-76. doi: 10.4049/jimmunol.179.11.7767.
10
TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity.系统性自身免疫中I型干扰素诱导的Toll样受体依赖性和非Toll样受体依赖性途径
Nat Med. 2007 May;13(5):543-51. doi: 10.1038/nm1590.
Zotero 插件