Department of Clinical and Experimental Medicine, University Federico II of Naples, Italy.
Dig Liver Dis. 2012 May;44(5):379-83. doi: 10.1016/j.dld.2011.12.012. Epub 2012 Jan 24.
Celiac patients report fatigue and reduced social activities, which may decrease physical activity. This study investigated the physical activity, fatigue and bone mineral density in celiac women at diagnosis and during diet.
The first group (n=48) had the bone mineral density measured at diagnosis and after 2 years of a gluten-free diet; in the second group (n=47) bone mineral density was measured at diagnosis and after 5 years of a gluten-free diet. Both groups completed a physical activity questionnaire and visual analogue scale for the perception of fatigue at diagnosis and follow-up. Data about smoking habits, alcohol use, presence of gastrointestinal symptoms, drug therapy and body mass index were also collected.
At diagnosis, the two groups were similar for all considered variables. At follow-up, the mean body mass index and physical activity questionnaire's score were similar to baseline. The bone density increased in both groups, whilst the physical activity questionnaire and visual analogue scale remained unchanged.
The improvement in bone density following a gluten-free diet was significant after 2 years; physical activity is frequently low and plays a minor role in determining the changes in bone mineral density.
乳糜泻患者报告疲劳和社交活动减少，这可能会降低身体活动量。本研究旨在调查诊断时和饮食治疗期间乳糜泻女性的身体活动、疲劳和骨密度。
第一组（n=48）在诊断时和无麸质饮食 2 年后测量骨密度；第二组（n=47）在诊断时和无麸质饮食 5 年后测量骨密度。两组均在诊断时和随访时完成身体活动问卷和疲劳视觉模拟量表。还收集了关于吸烟习惯、饮酒、胃肠道症状、药物治疗和体重指数的数据。
在诊断时，两组在所有考虑的变量上均相似。随访时，平均体重指数和身体活动问卷评分与基线相似。两组的骨密度均增加，而身体活动问卷和视觉模拟量表保持不变。
无麸质饮食 2 年后骨密度的改善显著；身体活动量通常较低，对骨矿物质密度的变化影响较小。
