Capriles Vanessa D, Martini Ligia A, Arêas José Alfredo G
Nutrition Department, School of Public Health, São Paulo University, São Paulo, Brazil.
Nutr Rev. 2009 Oct;67(10):599-606. doi: 10.1111/j.1753-4887.2009.00232.x.
Reduced bone mineral density (BMD) is frequently found in individuals with untreated celiac disease (CD), possibly due to calcium and vitamin D malabsorption, release of pro-inflammatory cytokines, and misbalanced bone remodeling. A gluten-free diet (GFD) promotes a rapid increase in BMD that leads to complete recovery of bone mineralization in children. Children may attain normal peak bone mass if the diagnosis is made and treatment is given before puberty, thereby preventing osteoporosis in later life. A GFD improves, but rarely normalizes, BMD in patients diagnosed with CD in adulthood. In some cases, nutritional supplementation may be necessary. More information on therapeutic alternatives is needed.
未经治疗的乳糜泻（CD）患者常出现骨矿物质密度（BMD）降低，这可能是由于钙和维生素D吸收不良、促炎细胞因子释放以及骨重塑失衡所致。无麸质饮食（GFD）可促进BMD迅速增加，从而使儿童的骨矿化完全恢复。如果在青春期前做出诊断并给予治疗，儿童可能获得正常的峰值骨量，从而预防晚年骨质疏松症。GFD可改善成年期被诊断为CD的患者的BMD，但很少使其恢复正常。在某些情况下，可能需要营养补充。需要更多关于治疗选择的信息。
