Medical Research Council, Centre for Causal Analysis in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Oakfield House, 15-23 Oakfield Grove, Clifton, Bristol BS8 2BN, United Kingdom.
J Clin Endocrinol Metab. 2012 Apr;97(4):1202-10. doi: 10.1210/jc.2011-2516. Epub 2012 Jan 25.
Vitamin D status is believed to be best indicated by serum 25-hydroxyvitamin D [25(OH)D; consisting of 25(OH)D₃ and 25(OH)D₂] that are obtained from different sources. Suboptimal vitamin D status is common and associated with adverse health outcomes.
The objectives were to report the prevalence and risk factors of vitamin D deficiency and determine associations of characteristics that have been shown to relate to total 25(OH)D with 25(OH)D₃ and 25(OH)D₂ concentrations.
The Avon Longitudinal Study of Parents and Children is a population-based contemporary birth cohort (children born in 1991-1992) from southwest England.
Seven thousand five hundred sixty children with serum 25(OH)D₃ and 25(OH)D₂ concentrations measured at the mean age of 9.9 yr participated in the study.
Vitamin D deficiency [total 25(OH)D concentration <20 ng/ml] was common (29%). The main risk factors were winter season, less time spent outdoors, low socioeconomic position, nonwhite ethnicity, older age, more advanced puberty stage, and female gender. Although there were some common risk factors for lower 25(OH)D₃ and 25(OH)D₂ concentrations (age, gender, puberty stage, body mass index, physical activity, household income, maternal education), several characteristics were associated with 25(OH)D₃ only (ethnicity, vitamin D intake, time spent outdoors, and UVB protection score) and others with 25(OH)D₂ only (protein and carbohydrate intake, parent's social class, and housing tenure).
Vitamin D deficiency was common in this contemporary U.K. cohort. Despite some overlap, there are differences in potential confounding structures for associations of 25(OH)D₃ and 25(OH)D₂ with health outcomes. These should be accounted for in future studies.
维生素 D 状态被认为最好由血清 25-羟维生素 D [25(OH)D;由 25(OH)D₃和 25(OH)D₂组成]来表示,这些物质来自不同的来源。维生素 D 状态不足很常见,与不良健康后果有关。
本研究旨在报告维生素 D 缺乏的流行率和危险因素,并确定与总 25(OH)D 相关的特征与 25(OH)D₃和 25(OH)D₂浓度之间的关联。
阿冯纵向研究父母和儿童是一个基于人群的当代出生队列(1991-1992 年出生的儿童),来自英格兰西南部。
共有 7560 名儿童在平均年龄为 9.9 岁时测量了血清 25(OH)D₃和 25(OH)D₂浓度,参与了本研究。
维生素 D 缺乏症(总 25(OH)D 浓度<20ng/ml)很常见(29%)。主要危险因素是冬季、户外活动时间少、社会经济地位低、非白种人、年龄较大、青春期阶段较晚、女性。虽然 25(OH)D₃和 25(OH)D₂浓度较低的一些共同危险因素(年龄、性别、青春期阶段、体重指数、身体活动、家庭收入、母亲教育),但一些特征仅与 25(OH)D₃相关(种族、维生素 D 摄入量、户外活动时间和 UVB 保护评分),而其他特征仅与 25(OH)D₂相关(蛋白质和碳水化合物摄入量、父母的社会阶层和住房所有权)。
在这个当代英国队列中,维生素 D 缺乏很常见。尽管存在一些重叠,但 25(OH)D₃和 25(OH)D₂与健康结果之间关联的潜在混杂结构存在差异。在未来的研究中应该考虑到这些差异。