Primus R J, Kellogg C K
University of Rochester, Department of Psychology, New York 14627.
Horm Behav. 1990 Sep;24(3):311-23. doi: 10.1016/0018-506x(90)90012-m.
This study examined the role of gonadal androgens during puberty on the development of environment-related social interaction (SI) in male rats. SI in an unfamiliar environment versus SI in a familiar environment was evaluated in young adult rats as a function of sex and gonadal status. Intact male rats at 60 days of age exhibited a differential response to the two environments, whereas SI in intact female rats at 60 days was equivalent in the two environments. Furthermore, male rats castrated as juveniles and tested for SI at 60 days displayed a pattern of environment-related SI similar to SI in intact adult female rats. This effect of juvenile castration on SI in male rats was prevented by chronic exposure to testosterone propionate (TP) over Days 30 through 60. SI in male rats castrated in adulthood, on the other hand, was not altered either 2 or 4 weeks postcastration. The results from this study indicate that pubertal secretions of gonadal androgen(s) are necessary for the development of environment-related SI in male rats. In contrast, secretions of gonadal androgens in adulthood do not appear to be critical for the continued expression of environment-related SI, as suggested by the observation that environment-related SI in male rats remains unchanged by castration in adulthood.
本研究探讨了青春期性腺雄激素对雄性大鼠环境相关社会互动（SI）发育的作用。在成年幼鼠中，根据性别和性腺状态评估陌生环境中的SI与熟悉环境中的SI。60日龄的完整雄性大鼠对两种环境表现出不同的反应，而60日龄的完整雌性大鼠在两种环境中的SI相当。此外，幼年时阉割并在60日龄时进行SI测试的雄性大鼠表现出与成年完整雌性大鼠相似的环境相关SI模式。在第30天至60天期间长期暴露于丙酸睾酮（TP）可防止幼年阉割对雄性大鼠SI的这种影响。另一方面，成年后阉割的雄性大鼠在阉割后2周或4周时SI均未改变。本研究结果表明，性腺雄激素的青春期分泌对于雄性大鼠环境相关SI的发育是必要的。相比之下，成年期性腺雄激素的分泌对于环境相关SI的持续表达似乎并不关键，成年阉割的雄性大鼠环境相关SI未改变这一观察结果表明了这一点。
