Center for Brain Research, Medical University of Vienna, 1090 Vienna, Austria.
Genes Dev. 2012 Jan 15;26(2):110-3. doi: 10.1101/gad.184945.111.
RNA-binding proteins (RBPs) exert many roles in the post-transcriptional regulation of gene expression in eukaryotic cells. However, our understanding of how they recognize their target RNAs in vivo remains limited. In the January 1, 2012, issue of Genes & Development, Patel and colleagues (p. 43-53) provide detailed mechanistic insights into how one of the best-studied RBPs, zipcode-binding protein 1 (ZBP1), recognizes a bipartite RNA sequence element within the β-actin mRNA.
RNA 结合蛋白 (RBPs) 在真核细胞中转录后基因表达的调控中发挥着多种作用。然而，我们对于它们如何在体内识别其靶 RNA 的理解仍然有限。在 2012 年 1 月 1 日的《基因与发育》杂志上，Patel 及其同事（第 43-53 页）提供了关于研究最为深入的 RBP 之一——zipcode-binding protein 1 (ZBP1)——如何识别 β-actin mRNA 中一个双部分 RNA 序列元件的详细机制见解。
