Bhattacharya S, Tripathi H N, Gupta V, Nigam Bharti, Khanna A
Department of Plastic Surgery, Sahara Hospital and Ajanta Hospital, Lucknow, Uttar Pradesh, India.
Indian J Plast Surg. 2011 Sep;44(3):474-7. doi: 10.4103/0970-0358.90826.
Toxic epidermal necrolysis (TEN) is associated with a significant mortality of 30-50% and long-term sequelae. Treatment includes early admission to a burn unit, where management with precise fluid, electrolyte, protein, and energy supplementation, moderate mechanical ventilation, and expert wound care can be provided. Specific treatment with immunosuppressive drugs or immunoglobulins did not show an improved outcome in most studies and remains controversial. We have treated the cutaneous lesions of seven patients of TEN with collagen sheet dressings and have found a significant reduction in morbidity. The sheets are a one-time dressing, easy to apply and they reduce fluid loss, prevent infection, reduce pain, avoid repeated dressings and gradually peal off as the underlying lesions heal.
中毒性表皮坏死松解症（TEN）的死亡率高达30%-50%，并伴有长期后遗症。治疗措施包括尽早入住烧伤科，在那里可以进行精确的液体、电解质、蛋白质和能量补充管理、适度的机械通气以及专业的伤口护理。在大多数研究中，使用免疫抑制药物或免疫球蛋白进行特异性治疗并未显示出更好的疗效，且仍存在争议。我们用胶原片敷料治疗了7例TEN患者的皮肤损伤，发现发病率显著降低。这些敷料是一次性使用的，易于应用，可减少液体流失、预防感染、减轻疼痛、避免反复换药，并且随着深层损伤的愈合会逐渐脱落。
