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放射治疗缓解肾细胞癌病例中外生性舌根转移瘤所致吞咽困难

Palliation of dysphagia with radiotherapy for exophytic base tongue metastases in a case of renal cell carcinoma.

作者信息

Wadasadawala Tabassum, Kumar Prabhash, Agarwal Jaiprakash, Ghosh-Laskar Sarbani

机构信息

Department of Radiation Oncology, Tata Memorial Hospital, Dr. Ernest Borges Road, Parel (East), Mumbai, India.

出版信息

Indian J Urol. 2011 Oct;27(4):550-2. doi: 10.4103/0970-1591.91452.

Abstract

Base tongue involvement is a rare presentation of lingual metastases from renal cell carcinoma. A 48-year-old gentleman was treated with open radical nephrectomy and adjuvant radiotherapy for Stage II Furhman grade I clear cell carcinoma of the left kidney at an outside hospital. He presented metachronously 5 years later with progressive dysphagia and change of voice. Clinicoradiological evaluation revealed a large exophytic mass in the oropharynx with epicenter in the right base of tongue. Metastatic workup revealed widespread dissemination to multiple organs and bone. In view of predominant symptom of dysphagia, base tongue metastasis was treated with protracted course of palliative radiotherapy to a dose of 50 Gy in conventional fractionation over 5 weeks. This resulted in excellent and durable response at the base tongue lesion (till the time of last follow-up). Radiation therapy is an acceptable palliative strategy for advanced lingual metastasis as it produces prompt relief of pain, bleeding, and dysphagia.

摘要

舌根受累是肾细胞癌舌部转移的一种罕见表现。一名48岁男性在外地医院因左肾II期富尔曼1级透明细胞癌接受了开放性根治性肾切除术及辅助放疗。5年后,他出现了渐进性吞咽困难和声音改变。临床放射学评估显示口咽有一个巨大的外生性肿块,中心位于右舌根。转移灶检查显示已广泛扩散至多个器官和骨骼。鉴于主要症状为吞咽困难,对舌根转移灶进行了为期5周的姑息性放疗,常规分割剂量为50 Gy。这导致舌根病变出现了良好且持久的反应(直至最后一次随访时)。放射治疗是晚期舌部转移可接受的姑息治疗策略,因为它能迅速缓解疼痛、出血和吞咽困难。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18d6/3263231/246bb0b5d26f/IJU-27-550-g001.jpg

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