Nasri Hamidreza, Mayel Yadollah, Sheikhvatan Mehrdad, Forood Afsaneh
Associate Professor, Physiology Research Center, Department of Cardiology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
J Res Med Sci. 2011 Aug;16(8):1026-31.
Relationship between premature menopause and presence, severity and life-threatening events of coronary artery disease (CAD) has been suggested in recent observations. The present study tried to assess relationship between age of menopause and severity of CAD in a sample of women with suspected CAD.
In a cross-sectional study, we included 189 consecutive women with suspected CAD that were candidate for coronary angiography and admitted to the Shafa hospital in Kerman city. Our final population for analysis included women who underwent natural menopause (n = 148) or premature menopause (n = 41). CAD severity was classified according to the number of coronary artery stenosis ≥ 50% in coronary angiography.
Among 189 study patients with suspected CAD, 22.0% of those with early menopause and 23.6% of those with normal menopause suffered three coronary vessels involvement, while normal angiography features was shown in 39.0%o and 40.5%>, respectively. Regarding severity of CAD and left main lesions, no significant differences were found between the patients with and without premature menopause. According to the multivariable logistic regression model and with the presence of other patients' variables as cofounders, age of menopause could not predict the presence and severity of CAD in patients with suspected CAD. However, patients' age (OR: 1.11, p < 0.001) and family history of CAD (OR: 2.05, p = 0.04) were main predictors of the severity of CAD in these patients.
Premature menopause does not predict occurrence or severity of CAD in women with suspected CAD, but women age and their family history of CAD are main predictors of the severity of CAD.
近期观察表明，过早绝经与冠状动脉疾病（CAD）的存在、严重程度及危及生命的事件之间存在关联。本研究旨在评估疑似CAD女性样本中绝经年龄与CAD严重程度之间的关系。
在一项横断面研究中，我们纳入了189例连续的疑似CAD女性患者，这些患者均为冠状动脉造影的候选对象，并入住克尔曼市的沙法医院。我们用于分析的最终人群包括自然绝经的女性（n = 148）或过早绝经的女性（n = 41）。CAD严重程度根据冠状动脉造影中冠状动脉狭窄≥50%的数量进行分类。
在189例疑似CAD的研究患者中，过早绝经患者中有22.0%、正常绝经患者中有23.6%出现三支冠状动脉受累，而正常血管造影特征分别在39.0%和40.5%的患者中出现。关于CAD的严重程度和左主干病变，过早绝经患者与未过早绝经患者之间未发现显著差异。根据多变量逻辑回归模型，并将其他患者变量作为混杂因素，绝经年龄无法预测疑似CAD患者中CAD的存在和严重程度。然而，患者年龄（OR：1.11，p < 0.001）和CAD家族史（OR：2.05，p = 0.04）是这些患者中CAD严重程度的主要预测因素。
过早绝经不能预测疑似CAD女性中CAD的发生或严重程度，但女性年龄及其CAD家族史是CAD严重程度的主要预测因素。
