Ashrafi Vahid, Yazdi Amirhossein, Farhadian Maryam
Cardiovascular Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Cardiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Med J Islam Repub Iran. 2023 Jun 19;37:69. doi: 10.47176/mjiri.37.69. eCollection 2023.
A positive family history (FH) of coronary artery disease (CAD) is considered an independent risk factor for developing CAD. However, the relationship between the occurrence, angiographic anatomical location of the stenosis, and extent of CAD and the risk factors in the patients and their relatives is not well defined. Evaluation of this relationship is our main goal in this study.
In this descriptive cross-sectional study, the FH data for CAD and premature death in first-and second-degree relatives, angiographic anatomical location of the stenosis, the extent of CAD in the patients and their relatives, as well as the relationship between other risk factors and the extent of CAD, were collected from 300 adult patients undergoing coronary angiography at Farshchian cardiovascular hospital in Hamadan (Iran) between March 2020 and 2021. SPSS 24 and the chi-square, Fisher exact, and student t tests were used to analyze data. The significance level was considered < 0.05.
Out of 300 patients, 185 (61.7%) were men and 115 (38.3%) were women. A total of 177 patients (59%) in maternal and 82 patients (27.3%) in paternal relatives had an FH of CAD. There was a significant relationship between the severity of coronary artery involvement and risk factors ( < 0.001). Moreover, there was no significant relationship between the location of coronary artery involvement of the right coronary artery, left coronary artery, and left anterior descending artery and the severity of involvement of patients undergoing coronary angiography and their first- and second-degree relatives ( = 0.480).
Our findings suggest that there was no significant relationship between the anatomical location of the stenosis and the number of vessels involved and the FH of the patients. In patients with an FH, the extent of CAD significantly increased according to their risk factors for heart disease.
冠状动脉疾病（CAD）的阳性家族史（FH）被认为是发生CAD的独立危险因素。然而，CAD的发生、狭窄的血管造影解剖位置、CAD的程度与患者及其亲属的危险因素之间的关系尚不明确。评估这种关系是本研究的主要目标。
在这项描述性横断面研究中，收集了2020年3月至2021年期间在伊朗哈马丹法尔什奇安心血管医院接受冠状动脉造影的300例成年患者的CAD家族史数据以及一级和二级亲属过早死亡情况、狭窄的血管造影解剖位置、患者及其亲属的CAD程度，以及其他危险因素与CAD程度之间的关系。使用SPSS 24软件以及卡方检验、Fisher确切概率检验和学生t检验进行数据分析。显著性水平设定为<0.05。
300例患者中，185例（61.7%）为男性，115例（38.3%）为女性。共有177例患者（59%）的母系亲属和82例患者（27.3%）的父系亲属有CAD家族史。冠状动脉受累严重程度与危险因素之间存在显著关系（<0.001）。此外，右冠状动脉、左冠状动脉和左前降支冠状动脉受累位置与接受冠状动脉造影患者及其一级和二级亲属的受累严重程度之间无显著关系（=0.480）。
我们的研究结果表明，狭窄的解剖位置和受累血管数量与患者的家族史之间无显著关系。在有家族史的患者中，CAD的程度根据其心脏病危险因素显著增加。
