Synovitis in spondyloarthritides.
作者信息
Appel Heiner, Braun Jürgen
机构信息
Charité Berlin, Campus Benjamin Franklin, Department of Gastroenterology, Infectiology and Rheumatology, Germany.
出版信息
Open Rheumatol J. 2011;5:123-6. doi: 10.2174/1874312901105010123. Epub 2011 Dec 30.
Abstract
Recent studies using magnetic resonance imaging have suggested that the subchondral bone marrow and the entheses are the sites which are primarily involved in the peripheral and axial inflammation found in patients with spondyloarthritides. Histopathological analyses indicated that the typical morphological features at these sites reflect an inflammation (osteitis) at the bone cartilage interface and in the subchondral bone marrow. This finding implies that synovitis may be of minor importance, especially in comparison to other inflammatory joint diseases such as rheumatoid arthritis. Here, we summarize current available knowledge on synovial involvement in inflammatory processes related to SpA.
摘要
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本文引用的文献
1
Different response to rituximab in tumor necrosis factor blocker-naive patients with active ankylosing spondylitis and in patients in whom tumor necrosis factor blockers have failed: a twenty-four-week clinical trial.
Arthritis Rheum. 2010 May;62(5):1290-7. doi: 10.1002/art.27383.
2
Absence of a classically activated macrophage cytokine signature in peripheral spondylarthritis, including psoriatic arthritis.
Arthritis Rheum. 2009 Apr;60(4):966-75. doi: 10.1002/art.24406.
3
Inflammatory lesions of the spine on magnetic resonance imaging predict the development of new syndesmophytes in ankylosing spondylitis: evidence of a relationship between inflammation and new bone formation.
Arthritis Rheum. 2009 Jan;60(1):93-102. doi: 10.1002/art.24132.
4
Critical appraisal of assessment of structural damage in ankylosing spondylitis: implications for treatment outcomes.
Arthritis Rheum. 2008 Mar;58(3):649-56. doi: 10.1002/art.23260.
5
The abundant synovial expression of the RANK/RANKL/Osteoprotegerin system in peripheral spondylarthritis is partially disconnected from inflammation.
Arthritis Rheum. 2008 Mar;58(3):718-29. doi: 10.1002/art.23290.
6
Immunohistologic analysis of zygapophyseal joints in patients with ankylosing spondylitis.
Arthritis Rheum. 2006 Sep;54(9):2845-51. doi: 10.1002/art.22060.
7
Pathogenesis of spondyloarthritis: insights from synovial membrane studies.
Curr Rheumatol Rep. 2006 Aug;8(4):275-82. doi: 10.1007/s11926-006-0008-4.
8
Concepts and epidemiology of spondyloarthritis.
Best Pract Res Clin Rheumatol. 2006 Jun;20(3):401-17. doi: 10.1016/j.berh.2006.02.001.
9
Immunohistochemical analysis of hip arthritis in ankylosing spondylitis: evaluation of the bone-cartilage interface and subchondral bone marrow.
Arthritis Rheum. 2006 Jun;54(6):1805-13. doi: 10.1002/art.21907.
10
Tumor necrosis factor alpha blockade treatment down-modulates the increased systemic and local expression of Toll-like receptor 2 and Toll-like receptor 4 in spondylarthropathy.
Arthritis Rheum. 2005 Jul;52(7):2146-58. doi: 10.1002/art.21155.
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