Manabe Yuri, Norikane Takashi, Yamamoto Yuka, Murao Mitsumasa, Shimada Hiromi, Wakiya Risa, Nakashima Shusaku, Dobashi Hiroaki, Nishiyama Yoshihiro
Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan.
EJNMMI Res. 2023 Feb 15;13(1):15. doi: 10.1186/s13550-023-00964-9.
We aimed to evaluate the correlation between 2-deoxy-2-[F]fluoro-D-glucose (FDG) uptake and disease activity assessed by serum inflammatory biomarker levels in patients with spondyloarthritis (SpA).
A total of 36 SpA patients (24 untreated and 12 treated) were examined using FDG positron emission tomography (PET)/computed tomography and classified into axial SpA (axSpA) and peripheral SpA (pSpA). FDG uptake was evaluated in 23 regions of the body and scored as follows: 0 = less than liver uptake; 1 = more than or equal to liver uptake; and 2 = more than or equal to twice liver uptake. A score of 1 or 2 was considered positive. The number of positive regions and the total score were counted in each patient. The maximum standardized uptake value (SUVmax) was calculated for each region, and maximum SUVmax (MaxSUVmax) was used as a representative value. Correlation of PET findings with serum inflammatory biomarker levels, including C-reactive protein (CRP), erythrocyte sedimentation rate, and matrix metalloproteinase 3 (MMP-3), was analyzed.
All but two patients had at least one positive lesion. PET indices correlated significantly with most of the serum inflammatory biomarker levels in untreated SpA, but not in treated SpA. Further, MaxSUVmax, number of positive regions, and total score correlated significantly with CRP (all P values < 0.001), and the number of positive regions (P = 0.012) and total score (P = 0.007) correlated significantly with MMP-3 in untreated pSpA. PET indices did not correlate with any serum inflammatory biomarker level in untreated axSpA.
FDG uptake in untreated pSpA correlated significantly with serum inflammatory biomarker levels.
我们旨在评估脊柱关节炎（SpA）患者中2-脱氧-2-[F]氟-D-葡萄糖（FDG）摄取与通过血清炎症生物标志物水平评估的疾病活动之间的相关性。
总共36例SpA患者（24例未治疗和12例已治疗）接受了FDG正电子发射断层扫描（PET）/计算机断层扫描检查，并分为轴向SpA（axSpA）和外周SpA（pSpA）。在身体的23个区域评估FDG摄取，并按以下方式评分：0 =低于肝脏摄取；1 =高于或等于肝脏摄取；2 =高于或等于肝脏摄取的两倍。评分为1或2被视为阳性。计算每位患者的阳性区域数量和总分。计算每个区域的最大标准化摄取值（SUVmax），并将最大SUVmax（MaxSUVmax）用作代表值。分析PET结果与血清炎症生物标志物水平（包括C反应蛋白（CRP）、红细胞沉降率和基质金属蛋白酶3（MMP-3））之间的相关性。
除两名患者外，所有患者至少有一个阳性病变。PET指标与未治疗的SpA中大多数血清炎症生物标志物水平显著相关，但与已治疗的SpA无关。此外，在未治疗的pSpA中，MaxSUVmax、阳性区域数量和总分与CRP显著相关（所有P值<0.001），阳性区域数量（P = 0.012）和总分（P = 0.007）与MMP-3显著相关。在未治疗的axSpA中，PET指标与任何血清炎症生物标志物水平均无相关性。
未治疗的pSpA中的FDG摄取与血清炎症生物标志物水平显著相关。
