Henriquez C S, Plonsey R
Department of Biomedical Engineering, Duke University, Durham, NC 27706.
IEEE Trans Biomed Eng. 1990 Sep;37(9):861-75. doi: 10.1109/10.58597.
Previous evaluations of the cylindrical bidomain model of a bundle of cardiac tissue, have been obtained by using an analytic function for the transmembrane potential and assuming the activating wavefront through the bundle cross section is planar. In this paper, nonlinear membrane kinetics are introduced into the bidomain membrane and equal anisotropy ratios are assumed, permitting the transmembrane potential to be computed and its behavior examined at different depths in the bundle and for different values of conductivity and bundle diameters. In contrast with single fiber models, the bundle model reveals that the shape of the action potential is influenced by tissue resistivities. In addition, the steady-state activation wavefront through the cross-section perpendicular to the long axis of the bundle is not planar and propagates with a velocity that lies between that of a single fiber in an unbounded volume and a single fiber in a restricted extracellular space. In general, the bundle model is shown to be significantly better than the classical single fiber model in describing the behavior of real cardiac tissue.
先前对一束心脏组织的圆柱双域模型的评估，是通过使用跨膜电位的解析函数并假设穿过束横截面的激活波前是平面的来获得的。在本文中，将非线性膜动力学引入双域膜，并假设各向异性比率相等，从而能够计算跨膜电位，并在束的不同深度以及不同电导率和束直径值下检查其行为。与单纤维模型相比，束模型表明动作电位的形状受组织电阻率的影响。此外，穿过垂直于束长轴的横截面的稳态激活波前不是平面的，并且以介于无界体积中的单纤维和受限细胞外空间中的单纤维之间的速度传播。一般来说，在描述真实心脏组织的行为方面，束模型显示出明显优于经典的单纤维模型。
