Ashman R B
Department of Pathology, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands.
Immunol Cell Biol. 1990 Jun;68 ( Pt 3):179-85. doi: 10.1038/icb.1990.25.
Inbred mice can be classified as susceptible or resistant to systemic infection with the yeast Candida albicans by histopathological evaluation of tissue lesions. Candida-specific memory T cell responses generated by resistant BALB/c mice are vigorous and sustained, whereas those displayed by susceptible CBA/H mice are weak. When spleen cells from immune mice were activated by culture with candida antigens in vitro, and injected into syngeneic and allogeneic recipients in the absence of further antigenic stimulation, cells from CBA/H mice induced a specific inflammatory response only in CBA/H recipients. In contrast, cells from immune BALB/c mice showed no specific activity. The effector cells were identified as T cells of the cytotoxic/suppressor subclass (CD4-, CD8+); and analysis in various F1 hybrid mice showed that reactivity was expressed only in animals carrying CBA/H genes. The data thus indicate that susceptibility to C. albicans infection is associated with the induction of a T cell subpopulation that has the potential to react specifically against unmodified self antigens expressed by the susceptible strain.
通过对组织损伤进行组织病理学评估，近交系小鼠可被分类为对白色念珠菌系统性感染易感或有抗性。抗性BALB/c小鼠产生的念珠菌特异性记忆T细胞反应强烈且持久，而易感CBA/H小鼠的反应则较弱。当用念珠菌抗原体外培养激活免疫小鼠的脾细胞，并在无进一步抗原刺激的情况下将其注射到同基因和异基因受体中时，CBA/H小鼠的细胞仅在CBA/H受体中诱导出特异性炎症反应。相比之下，免疫BALB/c小鼠的细胞未表现出特异性活性。效应细胞被鉴定为细胞毒性/抑制亚类（CD4-，CD8+）的T细胞；对各种F1杂交小鼠的分析表明，反应性仅在携带CBA/H基因的动物中表现出来。因此，数据表明，对白色念珠菌感染的易感性与一种T细胞亚群的诱导有关，该亚群有可能对易感菌株表达的未修饰自身抗原产生特异性反应。
