Escobar André, Valadão Carlos A A, Brosnan Robert J, Denicol Anna C, Flôres Fabíola N, Thiesen Roberto, Coelho Cássia M M
Department of Veterinary Clinics and Surgery, Faculdade de Ciências Agrárias e Veterinárias, São Paulo State University, Jaboticabal, Brazil.
Am J Vet Res. 2012 Feb;73(2):183-8. doi: 10.2460/ajvr.73.2.183.
To determine the minimum anesthetic concentration (MAC) for sevoflurane and measure the dose and temporal effects of butorphanol on the MAC for sevoflurane in guineafowl.
10 healthy adult guineafowl (Numida meleagris).
Each bird was anesthetized with sevoflurane, and a standard bracketing method was used to measure the MAC in response to a noxious electrical stimulus. Subsequently, conditions were adjusted so that each bird was anesthetized with sevoflurane at a fraction of its respective MAC (eg, 0.7 times the MAC for that bird). Butorphanol tartrate (2 mg/kg, IV) was administered, and a noxious stimulus was applied every 15 minutes until the bird moved in response. The reduction in MAC was estimated with logistic regression by use of a standard quantal method. After an interval of ≥ 1 week, the MAC reduction experiment was repeated with an increased butorphanol dosage (4 mg/kg).
Individual mean ± SE MAC for sevoflurane was 2.9 ± 0.1%. At 15 minutes after administration of 2 mg of butorphanol/kg, estimated reduction in the MAC for sevoflurane was 9 ± 3%. At 15 and 30 minutes after administration of 4 mg of butorphanol/kg, estimated reduction in the MAC for sevoflurane was 21 ± 4% and 11 ± 8%, respectively.
In guineafowl, the MAC for sevoflurane was similar to values reported for other species. Increasing the butorphanol dosage decreased the MAC for sevoflurane, but the effect was small and of short duration for dosages up to 4 mg/kg.
确定几内亚凤头珠鸡七氟醚的最低肺泡有效浓度（MAC），并测量布托啡诺对几内亚凤头珠鸡七氟醚MAC的剂量及时间效应。
10只健康成年几内亚凤头珠鸡（珠鸡）。
每只鸡用七氟醚麻醉，采用标准夹值法测量对有害电刺激反应时的MAC。随后，调整条件使每只鸡以其各自MAC的一部分（如该鸡MAC的0.7倍）用七氟醚麻醉。静脉注射酒石酸布托啡诺（2 mg/kg），每15分钟施加一次有害刺激，直至鸡出现反应性移动。采用标准的定量方法，通过逻辑回归估计MAC的降低情况。间隔≥1周后，增加布托啡诺剂量（4 mg/kg）重复MAC降低实验。
七氟醚的个体平均±标准误MAC为2.9±0.1%。给予2 mg/kg布托啡诺后15分钟，七氟醚MAC的估计降低值为9±3%。给予4 mg/kg布托啡诺后15分钟和30分钟，七氟醚MAC的估计降低值分别为21±4%和11±8%。
在几内亚凤头珠鸡中，七氟醚的MAC与其他物种报道的值相似。增加布托啡诺剂量可降低七氟醚的MAC，但对于高达4 mg/kg的剂量，其效果较小且持续时间较短。
